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Biopharmaceuticals are medical drugs produced using biotechnology. They include proteins (including antibodies), nucleic acids (DNA, RNA or antisense oligonucleotides) and living microorganisms like virus and bacteria where the virulance of viruses and bacteria is reduced by the process of atenuation, they can be used for therapeutic or in vivo diagnostic purposes, and are produced by means other than direct extraction from a native (non-engineered) biological source.

Classification of biopharmaceuticals

  • Blood factors (Factor VIII and Factor IX)
  • Thrombolytic agents (tissue plasminogen activator)
  • Hormones (insulin, glucagon, growth hormone, gonadotrophins)
  • Haematopoietic growth factors (Erythropoietin, colony stimulating factors)
  • Interferons (Interferons-α, -β, -γ)
  • Interleukin-based products (Interleukin-2)
  • Vaccines (Hepatitis B surface antigen)
  • Monoclonal antibodies (Various)
  • Additional products (tumour necrosis factor, therapeutic enzymes)

Uses

  • Erythropoietin - Treatment of anaemia
  • Interferon-α - Treatment of leukaemia
  • Interferon-β - Treatment of multiple sclerosis
  • Monoclonal antibody - Treatment of rheumatoid arthritis
  • Colony stimulating factors - Treatment of neutropenia
  • Glucocerebrosidase - Treatment of Gaucher's disease

Source: Wikipedia

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