Follow RSS for latest reports on this topicBiomarkers - Market Research and Reports

The NIH defines a biomarker as "a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention."

A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

They are important in new diagnostic tests, and are used in screening, research and genetic studies. As more and more sensitive methods allow us to identify more biomarkers, they help create a more detailed picture about a particular disease.

Biomarker-driven personalized cancer therapy

There is growing interest in biomarker-driven personalized cancer therapy (precision medicine). Molecular tests, including next generation sequencing, have been developed to detect biomarkers that have the potential to predict response of cancers to particular targeted therapies. Detection of cancer-related biomarkers is only the first step in the battle, deciding what therapy options to pursue can be more difficult, especially when tumors have more than one potentially actionable aberration. Further, different mutations/variants in a single gene may have different functional consequences, and response to targeted agents may be context dependent.

Early clinical trials with new molecular entities are increasingly conducted in a biomarker-selected fashion, and even when trials are not biomarker-selected, much effort is placed on enrolling patients onto clinical trials where they have the highest probability of response. 

The development of trastuzumab for human epidermal growth factor 2 (HER2)-positive breast cancer dramatically altered the outcome of patients with HER2-positive disease, providing a prime example for the success of biomarker-driven, personalized cancer therapy. Objective response rates for first-line trastuzumab treatment in patients with and without HER2 gene amplification by fluorescence in situ hybridization (FISH) analysis were 34% and 7%, respectively (Vogel et al., 2002), illustrating the efficacy of targeted therapies in tumors harboring molecular aberrations predicted to mediate therapy sensitivity.

Over a dozen targeted therapies have been approved with companion diagnostic tests, assays that predict tumor response to therapy, aimed at assisting in the decision of which targeted therapy strategies should be utilized for specific patients. These include assessment of BRAF V600 mutations for administration of anti-RAF and anti-MEK therapies in melanoma and BCR-ABL gene fusions for the use of imatinib in treating chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).

BioPortfolio's Easy Ordering System

  1. Search for the report you need from our store
  2. Make online payment with our easy checkout process
  3. Receive PDF report via email

Easy Online Payment or Pro Forma Invoice

We accept the following credit cards...



or can supply a pro-forma invoice if required.

Related Reports:

We found over 40 reports that matched your search.

Next 40 Matches >

Refine your search, and find more matches, using the form above.

Global Cancer Biomarkers Market Size study, by Profiling Technology (Omic Technologies, Imaging Technologies, Immunoassays, Cytogenetics-based Tests), by Biomolecule (Genetic Biomarkers, Protein Biomarkers, Glyco-biomarkers), by Cancer Type (Breast Cancer, Lung Cancer, Colorectal Cancer, Prostate Cancer, Stomach Cancer, Others), by Application (Diagnostics, Drug Discovery and Development, Prognost

Global Cancer Biomarkers Market is valued at approximately at USD 10.9 billion in 2019 and is anticipated to grow with a healthy growth rate of more than 11.8% over the forecast period 2020-2027. According to the World Health Organization (WHO), cancer is the second major cause of death around the world and is responsible for nearly 70% of deaths occurred in the developed and developing countries ...Read More >>>

Published:
2020-08-28

Published by: Bizwit Research and Consulting

Prices Starting From:
$4950

Nonalcoholic steatotic hepatitis (NASH) Market, By types(serums biomarkers, Hepatic fibrosis biomarkers, Oxidative stress biomarkers, Apoptosis biomarkers, and others), by application (Pharma, Hospitals, Academic Institutes) And Geography (North America, Europe, Asia Pacific, And Rest Of The World) – Analysis, Share, Trends, Size, & Forecast From 2016 – 2027- COVID- 19 Updated

The Nonalcoholic steatotic hepatitis (NASH) market is estimated to represent a global market of USD 3,898.6 million by 2019 with growth rate of 25.2%. Nonalcoholic steatotic hepatitis (NASH) is the most prevalent form of progressive liver disease condition. The market is categorized into serums biomarkers, Hepatic fibrosis biomarkers, Oxidative stress biomarkers, Apoptosis biomarkers, and others....Read More >>>

Published:
2020-07-01

Published by: AnalystView

Prices Starting From:
$3250

Cancer Biomarkers Market by Profiling Technology (Omic Technologies, Imaging Technologies, Immunoassays, and Cytogenetics Based Tests), Biomolecules (Genetic Biomarkers, Protein Biomarkers, and Glycoprotein Biomarkers), Cancer Type (Breast Cancer, Lung Cancer, Prostate Cancer, Colorectal Cancer, Stomach Cancer, and Other Cancers), Application (Diagnostics, Drug Discovery and Development, Prognosti

Cancer biomarkers are biomolecules that specifies the existence of cancer or cancerous cells in the body. These are generally molecules that are released due to the presence of a tumor or a particular indication in the body to the presence of cancer. These molecules are densely distributed in tissues, urine, serum, blood, and other body fluids. Their expression levels serve as the basis or indicat...Read More >>>

Published:
2016-12-01

Published by: Allied Market Research

Prices Starting From:
$5370

Published:
2015-08-28

Published by: MarketsandMarkets

Prices Starting From:
$5650

We Stock...

{STICKYFOOTERMOBILE}