$8145 | Single User
$21095 | Global License

CAR-T Disease Outlook [2017] [Report Updated: 01-06-2017]

Published by FirstWord Pharma: 01 Jun 2017 | 97365 | In Stock

Introduction

Will CAR-T cell therapies shape the treatment of blood cancers in the next decade?


Anti-CD19 CAR-T cell therapies have demonstrated unprecedented response rates across patient subgroups of acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) with high unmet needs. How will the impressive efficacy and safety of these therapies pan out in the long-term? Key opinion leaders (KOLs) explore the clinical challenges and opportunities that face these exciting treatments across multiple haematological cancer settings. Experts discuss the logistical, pricing, reimbursement and market access (PR&MA) hurdles facing these novel therapies and how they can be overcome. Learn how KOLs see the future CAR-T therapy market evolving, and how they expect developers to successfully differentiate their CAR-T therapies in KOL Insight: CAR-T cell Therapy in Haematological Malignancy. Eight US KOLs also provide their candid views on the potential for next-generation approaches, allogeneic CAR-T therapies and other novel strategies


Take a tour of the report now:


The table of contents >

The key business questions answered >

The key KOL quotes >

See the therapies covered >

Find out who the KOLs are >

Review an extract from the report - 1 drug profile >

Top Takeaways


- Impressive responses achieved with anti-CD19 CAR-T but how important is long-term durability? Efficacy is unprecedented in relapsed/refractory patients with high unmet needs but how do KOLs view the long-term durability and persistence of CAR-T therapies?

- Which diseases show most benefit to CAR-T treatment and why? Anti-CD19 CAR-T cells have been investigated in acute lymphocytic leukaemia (ALL), chronic lymphocytic leukaemia (CLL), non-Hodgkin lymphoma (NHL). What are the key opportunities facing CAR-T in each disease and which ones are KOLs most excited about?

- What needs to be prioritised in terms of safety? Cytokine release syndrome (CRS) and neurotoxicity are associated with CAR-T treatment. How concerned are KOLs about safety of these treatments and how will side effects be managed going forward?

- What are the main logistical challenges facing autologous CAR-T cell therapies and how can they be overcome? Find out what logistical hurdles face autologous CAR-T cell therapies and what KOLs think can be done to overcome them.

- Pricing, reimbursement and market access of CAR-T cell therapy; what are KOL’s opinions? What key market barriers will CAR-T therapies face and will payers be prepared to fund them?

- Do next-generation CAR-T cell approaches ignite KOL excitement? Allogeneic ‘off-the-shelf’ CAR-T cells and CAR-T cells incorporating safety switches are all in the early-stage pipeline. Which approach do KOLs think offers most promise and why?

- How do CAR-T cell therapies compare to gold-standard transplantation? Haematopoietic stem cell transplants (HSCT) are a cornerstone of treatment in haematological cancer. What parallels can KOLs draw from HSCT and do experts envisage CAR-T cell therapies eventually replacing transplantation?

- Which key players are best positioned for commercial success and why? Competition is mounting between Novartis, Kite Pharma and Juno Therapeutics but which key player is best positioned to carry CAR-T cell therapies forward according to the KOLs?

- How can companies differentiate themselves to market CAR-T therapies? What do CAR-T manufacturers need to do in order to bring these therapies to market in a competitive landscape?

- How will CAR-T cell therapies impact the future treatment algorithms of haematological cancers in 10 to 15 years? Can CAR-T therapies fulfil unmet needs and secure a niche in future treatment landscapes?

Quotes


“The response is impressive enough that I see [CAR-T therapies] being around in 10 to 15 years. Exactly where to use them and when to use them is still unknown. I see them being used for lymphoma, ALL, and in multiple myeloma, we'll have to see.”US Key Opinion Leader


“The responses for ALL are unprecedented. Somewhere between 80 to 90 percent of patients achieve a complete remission, and that's across different CAR programmes, and so it really does tell you it's a feature of the technology and not some secret at one company or one institution over another.”US Key Opinion Leader


A report based on expert knowledge


Key Opinion Leaders Interviewed for This Report


North American KOLs


Sample of therapies covered


Pipeline Therapies


- tisagenlecleucel-T (CTL019; Novartis)

- axicabtagene ciloleucel (KTE-019; Kite Pharma)

- JCAR014 (Juno Therapeutics)

- JCAR017 (Juno Therapeutics)

- JCAR018 (Juno Therapeutics)

- UCARTs (Cellectis/Pfizer/Cellectis)

- Plus 4 more - Download the complete list here >

Sample of KOLs interviewed


KOLs from North America


- Professor Michael R. Bishop, MD. Professor of Medicine and Director of Hematopoietic Stem Cell Transplantation Program at the University of Chicago.

- Dr. Marco L. Davila, MD, PhD. Medical oncologist in the Department of Blood and Marrow Transplantation at the Moffitt Cancer Center, Florida.

- Dr. Noelle Frey, MD, MSCE. Assistant Professor of Medicine at the Hospital of the University of Pennsylvania.

- Plus 4 more - Download the complete list here >

Money Back Guarantee


At FirstWord, we stand behind our reports. If you're not completely satisfied, we’ll refund your money. Guaranteed.


About FirstWord


FirstWord is an innovative industry intelligence leader serving over 240,000 Pharma and MedTech professionals worldwide. FirstWord offers a range of products and services designed to help your company gain a competitive edge by making key business decisions with speed and confidence.


FirstWord Pharma PLUS is a personalised and comprehensive intelligence service delivering up-to-the-minute pharma news, insight, analysis and expert views of importance to your company’s success.


FirstWord Reports deliver timely, need-to-know intelligence about your products, your competitors and your markets. Covering biosimilars, market access, medical affairs, sales & marketing, technology and therapy areas, FirstWord Reports provide expert views and intelligence on the challenges facing pharma today.

Table of Contents
for CAR-T Disease Outlook [2017] [Report Updated: 01-06-2017]

  • 1.Executive Summary

    2.Research Objectives

    3.Research Focus

    3.1 CAR-T cell technology – What are CAR-T cell therapies?

    4.Clinical Opportunities and Challenges for CAR-T cell therapies

    4.1 Key insights summary

    5.Commercial Opportunities and Challenges for CAR-T therapies

    5.1 Logistics of current autologous CAR-T cell therapies

    5.2 Key insights summary

    5.3 Pricing and Reimbursement (P&R) and Market Access (MA) of CAR-T cell therapies

    5.4 Key insights summary

    6.Disease-Specific Insights: Key Insights for CAR-T therapies in Haematological Malignancies

    6.1 Key insights summary

    7.Long-term Outlook for CAR-T cell therapies

    7.1 Key insights summary

    8.Evolution of Future Treatments

    9.Appendix

Additional Details

Publisher

FirstWord Pharma

Publisher Information

Reference

97365 |

Report Format

PDF

FirstWord Pharma Reports

Related Reports

TitleDate PublishedPrice fromMore Details
Diabetes -- KOL Insight and Consensus Outlook Modules
IntroductionThe medium term: battle lines are drawnThe fundamental drivers of the global diabetes ma...
01 May 2014 by FirstWord Pharma USD $7,900 More Info
Chronic Obstructive Pulmonary Disorder (COPD) - KOL Insight and Consensus Outlook
IntroductionThe prevalence of Chronic Obstructive Pulmonary Disorder (COPD) is increasing globally, ...
20 Jan 2014 by FirstWord Pharma USD $7,495 More Info
Consensus Outlook: Multiple Sclerosis
IntroductionOver the next five years, the global multiple sclerosis (MS) market is set to grow from ...
01 Dec 2013 by FirstWord Pharma USD $4,995 More Info
Hepatitis C: Game changing regimens to revolutionise treatment landscape - Consensus Outlook
IntroductionThe worldwide hepatitis C (HCV) market is forecast to grow from .7 billion in 2012 to ...
01 Dec 2013 by FirstWord Pharma USD $4,995 More Info
Consensus Outlook: Prostate Cancer- Competition intensifies in race to the top
IntroductionCharting the Future Prostate Cancer Market LandscapeThe prostate cancer market has exper...
01 Nov 2013 by FirstWord Pharma USD $4,995 More Info
The Impact of Mobile Health on Patient-Centric Disease Management
IntroductionBanks use them. So does the travel industry. And tastemakers are harnessing their power ...
01 Aug 2013 by FirstWord Pharma USD $695 More Info
Multiple Sclerosis -- KOL Insight and Consensus Outlook Modules
IntroductionThe multiple sclerosis treatment landscape has undergone dramatic changes over the past ...
12 Mar 2013 by FirstWord Pharma USD $7,495 More Info
The Top 10 Pharma Companies in 2017
Introduction...leading drivers and resistors to growthWith many of the world's largest pharmaceutica...
01 Mar 2013 by FirstWord Pharma USD $395 More Info
HIV -- KOL Insight and Consensus Outlook Modules
IntroductionWhat do frontline clinicians really think about current HIV treatment pathways and what ...
24 Feb 2013 by FirstWord Pharma USD $7,495 More Info
Therapy Trends: Alzheimer's Disease - Breaking new ground in disease modification
IntroductionIn 2012, the Alzheimer’s disease (AD) market was dealt a huge blow following negative re...
01 Dec 2012 by FirstWord Pharma USD $7,900 More Info

This report is published by FirstWord Pharma

Download Free Report Summary PDF

CAR-T Disease Outlook [2017] [Report Updated: 01-06-2017] | Download PDF Summary

Download our FREE report summary PDF. It contains all the information on these web pages, plus a Proforma Invoice request form, should you need it to satisfy your company's internal order procedures.

Ordering Information

Orders are processed immediately and you will be notified of the despatch date on confirmation of your order.

Accepted Card Types

Payment

Buy now using our secure payment system.

We Stock...

  • Allied Market Research
  • CBR Pharma
  • Current Partnering
  • Firstword
  • Global Data
  • Global Markets Direct
  • ICD Research
  • Infinti Research Technavio
  • Marketline
  • Markets and Markets
  • Micro Markets Monitor
  • MP Advisors
  • Venture Planning Group
  • GMR Data