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Multiple Myeloma - China Drug Forecast and Market Analysis to 2023
[Published by Global Data]

Published by Global Data: 01 Nov 2015 | 27218 | In Stock
Related Topics: Multiple Myeloma , Myeloma

Introduction

Multiple Myeloma - China Drug Forecast and Market Analysis to 2023

Summary

The Multiple Myeloma (MM) market is currently dominated by Velcade and Revlimid, and the market is set to undergo substantial growth between 2013 and 2023. The main drivers of growth will be the launch of monoclonal antibodies (mAbs) Empliciti and daratumumab, which will not only provide a new treatment option for MM patients, but will also lengthen the time between relapses, meaning that the duration of Revlimid and/or Velcade treatments will also be longer. Furthermore, the relatively mild safety profile of these mAbs and the significant efficacies demonstrated by these agents will mean that more MM patients will ultimately receive drug treatment. Label extensions of these mAbs, as well as of second-generation proteasome inhibitors ixazomib and Kyprolis, will further increase treatment options for these patients. The biggest constrainers of the MM market are the increasing cost-consciousness of healthcare providers, as the launch and subsequent label extensions of these pipeline agents will lead to a significant expense, which may impact uptake of these drugs. The patent expiries of Revlimid and Velcade will somewhat alleviate healthcare spending on multiple myeloma patients, which may assist in the uptake of mAbs and second-generation PIs in the multiple myeloma market.

The urban China market is expected to increase in size by 2023, although at a more modest rate compared to the other major markets. Uptake of new therapies will be limited in China compared to the other major markets. Management of the disease in China is still not fully developed, and drug reimbursement limitations restrict the use of expensive branded therapies, so the use of chemotherapies and unbranded agents such as thalidomide is preferred.

Scope

- Overview of Multiple Myeloma including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.

- Detailed information on the key drugs in China including product description, safety and efficacy profiles as well as a SWOT analysis.

- Sales forecast for the top drugs in China from 2014-2024.

- Analysis of the impact of key events as well the drivers and restraints affecting China Multiple Myeloma market.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return

- Stay ahead of the competition by understanding the changing competitive landscape for Multiple Myeloma.

- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential

- Make more informed business decisions from insightful and in-depth analysis of drug performance

- Obtain sales forecast for drugs from 2014-2024 in China.

Table of Contents
for Multiple Myeloma - China Drug Forecast and Market Analysis to 2023 [Published by Global Data]

  • 1 Table of Contents

    1 Table of Contents 2

    1.1 List of Tables 6

    1.2 List of Figures 10

    2 Introduction 11

    2.1 Catalyst 11

    2.2 Related Reports 12

    2.3 Upcoming Related Reports 12

    3 Disease Overview 13

    3.1 Etiology and Pathophysiology 13

    3.1.1 Etiology 13

    3.1.2 Pathophysiology 13

    3.2 Staging Systems 16

    3.3 Response and Relapse Criteria 17

    3.4 Symptoms 19

    3.5 Prognosis 20

    3.6 Quality of Life 21

    4 Disease Management 24

    4.1 Treatment Overview 24

    4.2 Diagnosis 25

    4.3 Clinical Practice 26

    4.3.1 Primary Therapy for SCT-Eligible Patients 27

    4.3.2 Primary Therapy for Non-SCT Patients 29

    4.3.3 Salvage/Relapse Therapy 30

    4.3.4 Leading Prescribed Drugs 31

    4.4 China (Urban) 34

    4.4.1 Diagnosis 35

    4.4.2 Clinical Practice 35

    5 Competitive Assessment 36

    5.1 Overview 36

    5.2 Product Profiles - Proteasome Inhibitors 36

    5.2.1 Velcade (Bortezomib) 36

    5.2.2 Kyprolis (Carfilzomib) 43

    5.3 Product Profiles - Immunomodulators 51

    5.3.1 Revlimid (Lenalidomide) 51

    5.3.2 Pomalyst/Imnovid (Pomalidomide) 58

    5.4 Other Therapeutic Classes 63

    6 Unmet Need and Opportunity 64

    6.1 Overview 64

    6.2 Treatment of High-Risk Patients 64

    6.2.1 Unmet Need 64

    6.2.2 Gap Analysis 65

    6.2.3 Opportunity 66

    6.3 Treatment of Patients with Smoldering Myeloma 66

    6.3.1 Unmet Need 66

    6.3.2 Gap Analysis 68

    6.3.3 Opportunity 68

    6.4 Treatment of Extramedullary Disease 69

    6.4.1 Unmet Need 69

    6.4.2 Gap Analysis 69

    6.4.3 Opportunity 70

    7 Pipeline Assessment 71

    7.1 Overview 71

    7.2 Promising Drugs in Clinical Development 71

    7.2.1 Farydak (Panobinostat) 71

    7.2.2 Ixazomib 78

    7.2.3 Empliciti (Elotuzumab) 83

    7.2.4 Daratumumab 89

    7.2.5 Aplidin (Plitidepsin) 94

    7.3 Promising Drugs in Early-Stage Development 98

    7.3.1 Oprozomib (ONX-0912) 98

    7.3.2 Filanesib 99

    7.3.3 SAR650984 99

    7.3.4 Marizomib 101

    7.3.5 Evofosfamide 101

    7.3.6 LGH447 102

    7.3.7 Selinexor (KPT-330) 102

    8 Market Outlook 104

    8.1 China (Urban) 104

    8.1.1 Forecast 104

    8.1.2 Key Events 107

    8.1.3 Drivers - China (Urban) 107

    8.1.4 Barriers - China (Urban) 108

    9 Appendix 110

    9.1 Bibliography 110

    9.2 Abbreviations 132

    9.3 Methodology 136

    9.4 Forecasting Methodology 136

    9.4.1 Diagnosed Multiple Myeloma Patients 136

    9.4.2 Percent of Drug-Treated Patients 137

    9.4.3 Drugs Included in Each Therapeutic Class 137

    9.4.4 Launch and Patent Expiry Dates 138

    9.4.5 General Pricing Assumptions 139

    9.4.6 Individual Drug Assumptions 140

    9.4.7 Pricing of Pipeline Agents 147

    9.4.8 Generic Erosion 154

    9.5 Primary Research - KOLs Interviewed for this Report 155

    9.6 Primary Research - High-Prescriber Survey 157

    9.7 About the Authors 158

    9.7.1 Analyst 158

    9.7.2 Therapy Director 158

    9.7.3 Epidemiologist 158

    9.7.4 Global Head of Healthcare 159

    9.8 About GlobalData 160

    9.9 Disclaimer 160

List Of Tables
in Multiple Myeloma - China Drug Forecast and Market Analysis to 2023 [Published by Global Data]

1.1 List of Tables

Table 1: Definition of the Classes of Myeloma 15

Table 2: Staging Systems for Multiple Myeloma 17

Table 3: IMWG Uniform Response Criteria for Multiple Myeloma: Response 18

Table 4: IMWG Uniform Response Criteria for Multiple Myeloma: Progression 18

Table 5: Symptoms of Multiple Myeloma 19

Table 6: Median Survival for Each Stage at Diagnosis of Multiple Myeloma 20

Table 7: Potential Diagnostic Markers that Predict Two-Year Disease Progression 21

Table 8: Summary of Prevalence and Clinical Outcomes of Translocations in Multiple Myeloma 21

Table 9: Treatment Guidelines for Multiple Myeloma 25

Table 10: Definition of the Classes of Myeloma 26

Table 11: Most Prescribed Drugs for Multiple Myeloma by Class in the Global Markets, 2014 31

Table 12: Most-Prescribed Drugs for Multiple Myeloma by Segment in the Global Markets, 2013 32

Table 13: Country Profile - China (Urban) 34

Table 14: Product Profile - Velcade 37

Table 15: Results from the Pivotal Phase III APEX Trial for Velcade 39

Table 16: Results from the Pivotal Phase III VISTA Trial for Velcade 40

Table 17 Results from the Subcutaneous versus Intravenous Velcade Phase III trial 40

Table 18: Common Grade 3 and 4 Adverse Events from Velcade Pivotal Clinical Trials 41

Table 19: Velcade SWOT Analysis, 2015 42

Table 20: Global Sales Forecast ($m) for Velcade, 2013-2023 42

Table 21: Product Profile - Kyprolis 44

Table 22 Summary of Phase III Pivotal Trial Results for Kyprolis 47

Table 23: Summary of Phase II Clinical Trial Efficacy Data for Kyprolis 48

Table 24 Summary of Adverse Events from Key Phase III Pivotal Trials for Kyprolis 49

Table 25: Kyprolis SWOT Analysis, 2015 50

Table 26: Global Sales Forecasts ($m) for Kyprolis, 2013-2023 51

Table 27: Product Profile - Revlimid 52

Table 28 Summary of Phase III Pivotal Trial Results for Revlimid in NDMM Patients 54

Table 29 Summary of Phase III Pivotal Trial Results for Revlimid in RRMM Patients 55

Table 30: Summary of Frequent Grade 3 and 4 AEs in a Phase III Trial for Revlimid 56

Table 31: Revlimid SWOT Analysis, 2015 57

Table 32: Global Sales Forecast ($m) for Revlimid, 2013-2023 57

Table 33: Product Profile - Pomalyst 58

Table 34: Summary of PFS, OS, and ORR from Phase II Trial Data for Pomalyst 60

Table 35: Summary of Phase III Trial Data for Pomalyst 61

Table 36: Pomalyst SWOT Analysis, 2015 62

Table 37: Global Sales Forecasts ($m) for Pomalyst, 2013-2023 62

Table 38: Summary of Other Therapeutic Classes, 2015 63

Table 39: Pipeline Product Profile - Farydak 72

Table 40: Summary of the Phase III PANORAMA 1 Trial of Farydak 75

Table 41: Summary of the Phase III PANORAMA 1 Trial of Farydak in Patients Who Recived at Least Two Prior Lines of Therapy (Including Velcade and an IMiD) 75

Table 42: Summary of the Phase II PANORAMA 2 Trial of Farydak 76

Table 43: Grade 3-4 Adverse Events in the Phase III PANORAMA 1 Trial of Farydak 76

Table 44: Farydak SWOT Analysis, 2015 78

Table 45: Global Sales Forecast ($m) for Farydak, 2013-2023 78

Table 46: Pipeline Product Profile - Ixazomib 79

Table 47: Response Results from the Phase II Study of Ixazomib 81

Table 48: Ixazomib SWOT Analysis, 2015 82

Table 49: Global Sales Forecast ($m) for Ixazomib, 2013-2023 83

Table 50: Pipeline Product Profile - Empliciti 84

Table 51: Summary of the Phase III ELOQUENT 2 trial of Empliciti 86

Table 52: Efficacy Results from the Phase II Study of Empliciti with Velcade and Dexamethasone 87

Table 53: Empliciti SWOT Analysis, 2015 88

Table 54: Global Sales Forecast ($m) for Empliciti, 2013-2023 88

Table 55: Pipeline Product Profile - Daratumumab 89

Table 56: Response Results from the Phase II Study of Daratumumab 91

Table 57: Daratumumab SWOT Analysis, 2015 93

Table 58: Global Sales Forecast ($m) for Ddaratumumab, 2013-2023 93

Table 59: Pipeline Product Profile - Aplidin 94

Table 60: Summary of Phase II Clinical Trial Results for Aplidin 96

Table 61: Summary of Grade 3 and 4 Adverse Events of Aplidin 96

Table 62: Aplidin SWOT Analysis, 2015 97

Table 63: Global Sales Forecast ($m) for Aplidin, 2013-2023 97

Table 64: Summary of Efficacy Data from the Phase Ib/II Clinical Trial of Oprozomib 99

Table 65: Summary of the Phase I Efficacy Results of SAR650984 100

Table 66: Summary of the Phase I Efficacy Results of Evofosfamide 102

Table 67: China (Urban) Sales Forecast, Multiple Myeloma, 2013-2023 ($m) 104

Table 68: Key Events Impacting Sales for Multiple Myeloma in China 2013-2023 107

Table 69: Chinese (Urban) Multiple Myeloma - Drivers, 2013-2023 107

Table 70: Chinese (Urban) Multiple Myeloma - Barriers, 2013-2023 108

Table 71: Multiple Myeloma Diagnosed Incidence, 2013-2023 137

Table 72: Multiple Myeloma Drugs and Pipeline agents, Launch Dates 138

Table 73: Multiple Myeloma Drugs and Pipeline agents, Anticipated Patent Expiries 139

Table 74: Average Cost of Therapy for Velcade 141

Table 75: Average Duration of Treatment (Weeks) for Velcade 141

Table 76: Average Cost of Therapy for Kyprolis ($) 143

Table 77: Average Duration of Treatment (Weeks) for Kyprolis 143

Table 78: Average Cost of Therapy for Revlimid ($) 144

Table 79: Average Duration of Treatment (Weeks) for Revlimid 145

Table 80: Average Cost of Therapy for Pomalyst/Imnovid ($) 146

Table 81 Average Duration of Treatment (Weeks) for Pomalyst/Imnovid 146

Table 82: Average Cost of Therapy for Farydak ($) 147

Table 83: Duration of Treatment (Weeks) for Farydak 148

Table 84: Average Cost of Therapy for Ixazomib ($) 149

Table 85: Duration of Treatment (Weeks) for Ixazomib 149

Table 86: Average Cost of Therapy for Empliciti ($) 150

Table 87: Duration of Treatment (Weeks) for Empliciti 151

Table 88: Average Cost of Therapy for Daratumumab ($) 152

Table 89: Duration of Treatment (Weeks) for Daratumumab 153

Table 90: Average Cost of Therapy for Daratumumab ($) 154

Table 91: Duration of Treatment (Weeks) for Daratumumab 154

Table 92: Numbers of Prescribers Surveyed in Each Country 157

List Of Figures, Charts and Diagrams
in Multiple Myeloma - China Drug Forecast and Market Analysis to 2023 [Published by Global Data]

1.2 List of Figures

Figure 1: SCT-Eligible Typical Patient Journey 27

Figure 2: Non-SCT-Eligible Typical Patient Journey 29

Figure 3: Velcade’s Phase III Development in Multiple Myeloma 38

Figure 4: Kyprolis’s Phase III Development in Multiple Myeloma 45

Figure 5: Revlimid’s Phase III Development in Multiple Myeloma 52

Figure 6: Pomalyst/Imnovid’s Phase III Development in Multiple Myeloma 59

Figure 7: Farydak’s Development in Multiple Myeloma 74

Figure 8: Dosing Schedule for Farydak 77

Figure 9: Ixazomib’s Development in Multiple Myeloma 80

Figure 10: Empliciti's Development in Multiple Myeloma 84

Figure 11: Daratumumab’s Development in Multiple Myeloma 91

Figure 12: Annual Chinese (Urban) Sales for Multiple Myeloma by Drug, 2013-2023 105

Figure 13: Chinese (Urban) Sales for Multiple Myeloma by Drug, 2013 and 2023 106

Additional Details

Publisher

Global Data

Publisher Information

Reference

27218 | GDHC306CFR

Number of Pages

161

Report Format

PDF

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