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Global Dermatology Market to 2022 - Innovative Pipeline and Increasing Uptake of Biologics to Diversify Treatment Options and Drive Strong Growth
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Published by GBI Research: 01 May 2016 | 25772 | In Stock
Related Topics: Dermatology

Introduction

Global Dermatology Market to 2022 - Innovative Pipeline and Increasing Uptake of Biologics to Diversify Treatment Options and Drive Strong Growth

Summary

Dermatological conditions are one of the most common types of disorders worldwide, and approximately one-third of the US population suffers from at least one active skin condition.For the past decades, the majority of the dermatology market has remained saturated with established products. However, the clinical and commercial success of biologics in the treatment of psoriasis, as well as advancements in the understanding of the disease pathways of many dermatological conditions, have led to a renewed interest from pharmaceutical companies in the dermatology market, and subsequently the emergence of an innovative pipeline.

This report covers all dermatological disorders, but there is a particular focus on three key diseases: atopic dermatitis, acne vulgaris and psoriasis, as these conditions have the highest prevalence and the largest pipeline. The global dermatology market was valued at .0 billion in 2015, and is projected to grow at a considerable Compound Annual Growth Rate (CAGR) of 7.73%, reaching .7 billion in 2022. Key drivers of this growth will be the uptake of recently approved premium biologics, as well as promising late-stage products that are expected to be highly valuable.

Scope

The dermatology market landscape is expected to change substantially with the advent of promising novel pipeline products.

Overall, there are 801 dermatology products in the pipeline, with biologics representing 37% of the pipeline, despite the fact that this molecule type represents only a small fraction of the marketed products landscape.

- Which molecular targets are most prominent within the pipeline?

- How do the key indications differ in terms of molecule type?

- How does the composition of the pipeline compare with that of the existing market?

- What mechanisms of action are most common for pipeline drugs?

Global revenues for the dermatology market are forecast to grow at a CAGR of 7.73%, from billion in 2015 to .7 billion in 2022.

- Which products will contribute to market growth most significantly, and which will achieve blockbuster status?

- Will the current market leaders retain their dominance over the forecast period, and how is their revenue share of the dermatology market set to change?

- What CAGR will these companies register in the forecast period?

Reasons to buy

This report will allow you to -

- Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis and the treatment options available at each stage of diagnosis.

- Visualize the composition of the dermatology market across each indication, in terms of dominant molecule types and targets, highlighting the key commercial assets and players.

- Analyze the dermatology pipeline and stratify by stage of development, molecule type and molecular target, with a granular breakdown across key indications.

- Understand the growth in patient epidemiology and market revenues for the dermatology market globally, and across the key players and product types.

- Stratify the market in terms of the split between generic and premium products, and assess the role of these product types in the treatment of the various dermatological conditions.

- Identify commercial opportunities in the dermatology deals landscape by analyzing trends in licensing and co-development deals.

Table of Contents
for Global Dermatology Market to 2022 - Innovative Pipeline and Increasing Uptake of Biologics to Diversify Treatment Options and Drive Strong Growth

  • 1 Table of Contents

    1 Table of Contents 5

    1.1 List of Tables 7

    1.2 List of Figures 8

    2 Introduction 10

    2.1 Therapy Area Introduction 10

    2.2 Symptoms 10

    2.3 Etiology and Pathophysiology 11

    2.3.1 Atopic Dermatitis 11

    2.3.2 Acne Vulgaris 12

    2.3.3 Psoriasis 13

    2.4 Co-morbidities and Complications 14

    2.5 Epidemiology Patterns and Forecasts - Prevalence and Patient Segmentation 14

    2.5.1 Atopic Dermatitis 15

    2.5.2 Acne Vulgaris 16

    2.5.3 Psoriasis 16

    2.6 Treatment 17

    2.6.1 Topical Corticosteroids 18

    2.6.2 Calcineurin Inhibitors 19

    2.6.3 Retinoids 19

    2.6.4 Systemic Immunosuppressive Agents 20

    2.6.5 Biologics 20

    2.6.6 Antihistamines 21

    2.6.7 Hormonal Therapy 21

    2.6.8 Moisturizers 21

    3 Key Marketed Products 23

    3.1 Overview 23

    3.2 Humira (adalimumab) 24

    3.3 Remicade (infliximab) 26

    3.4 Enbrel (etanercept) 27

    3.5 Stelara (ustekinumab) 29

    3.6 Neoral (cyclosporine) 30

    3.7 Protopic (tacrolimus) 32

    3.8 Elidel (pimecrolimus) 33

    3.9 Elocon (mometasone furoate) 34

    3.10 Differin (adapalene) 35

    3.11 Metolate (methotrexate) 36

    3.12 Clobex (clobetasol propionate) 36

    3.13 Conclusion 37

    4 Pipeline Landscape Assessment 38

    4.1 Overview 38

    4.2 Molecule Types in the Pipeline 41

    4.3 Molecular Targets in the Pipeline 43

    4.4 Clinical Trials 44

    4.4.1 Failure Rate by Stage of Development, Indication, Molecule Type and Molecular Target 45

    4.4.2 Clinical Trial Duration by Stage of Development, Indication, Molecule Type and Molecular Target 48

    4.4.3 Clinical Trial Size by Stage of Development, Indication, Molecule Type and Molecular Target 52

    4.4.4 Aggregate Clinical Program Size by Stage of Development, Indication, Molecule Type and Molecular Target 56

    4.5 Conclusion 61

    5 Multi-Scenario Market Forecast to 2022 62

    5.1 Overall Market Size 62

    5.2 Generic Penetration 63

    5.3 Revenue Forecast by Molecular Target 65

    5.3.1 Tumor Necrosis Factor-Alpha 65

    5.3.2 Interleukins 1, 4, 5, 12, 17 and 23 and Receptors 66

    5.3.3 Calcineurin 67

    5.3.4 Glucocorticoid Receptors 68

    5.3.5 Phosphodiesterase 4 69

    5.3.6 Revenue and Market Share Analysis by Company 70

    5.3.7 Assessment of Key Pipeline Products 80

    6 Company Analysis and Positioning 88

    6.1 Company Landscape 89

    6.2 Marketed and Pipeline Portfolio Analysis 90

    7 Strategic Consolidations 93

    7.1 Licensing Deals 93

    7.1.1 Deals by Region, Year and Value 93

    7.1.2 Deals by Stage of Development and Value 95

    7.1.3 Deals by Molecule Type, Mechanism of Action and Value 96

    7.1.4 Table for Licensing Deals Valued Above 0m 98

    7.2 Co-development Deals 99

    7.2.1 Deals by Region, Year and Value 99

    7.2.2 Deals by Stage of Development and Value 100

    7.2.3 Deals by Molecule Type, Mechanism of Action and Value 101

    7.2.4 Table for Co-development Deals Valued Above 0m 103

    8 Appendix 104

    8.1 References 104

    8.2 Table of Epidemiology Forecast 109

    8.3 Table of All Clinical Stage Pipeline Products 110

    8.4 Abbreviations 141

    8.5 Disease List 142

    8.6 Methodology 142

    8.6.1 Coverage 142

    8.6.2 Secondary Research 142

    8.6.3 Market Size and Revenue Forecasts 143

    8.6.4 Pipeline Analysis 143

    8.6.5 Competitive Landscape 143

    8.7 Contact Us 144

    8.8 Disclaimer 144

List Of Tables
in Global Dermatology Market to 2022 - Innovative Pipeline and Increasing Uptake of Biologics to Diversify Treatment Options and Drive Strong Growth

1.1 List of Tables

Table 1: Dermatology, Global, Epidemiology of Dermatological Disorders, 2015 15

Table 2: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Humira, 2015 25

Table 3: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Remicade, 2015 26

Table 4: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Enbrel, 2015 28

Table 5: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Stelara, 2015 29

Table 6: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Neoral, 2015 31

Table 7: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Protopic, 2015 32

Table 8: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Elidel, 2015 34

Table 9: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Elocon, 2015 34

Table 10: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Differin, 2015 35

Table 11: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Metolate, 2015 36

Table 12: Dermatology Therapeutics Market, Global, Approved Dermatology Indications for Clobex, 2015 37

Table 13: Dermatology Therapeutics Market, Global, Annual Revenue Forecast for Key Products ($bn), 2015-2022 63

Table 14: Dermatology, Global, Usage of Generics Across Key Indications, 2015 65

Table 15: Dermatology Therapeutics Market, Global, Forecast Revenue by Company, 2015-2022 70

Table 16: Dermatology Therapeutics Market, Global, Licensing Deals, 2006-2016 98

Table 17: Dermatology Therapeutics Market, Global, Co-development Deals, 2006-2016 103

Table 18: Epidemiology Patterns for Atopic Dermatitis, 2015-2022 109

Table 19: Epidemiology Patterns for Acne Vulgaris, 2015-2022 109

Table 20: Epidemiology Patterns for Psoriasis, 2015-2022 109

Table 21: Dermatology, Global, Table of all Clinical Stage Pipeline Products, 2016 110

Table 22: Abbreviations 141

List Of Figures, Charts and Diagrams
in Global Dermatology Market to 2022 - Innovative Pipeline and Increasing Uptake of Biologics to Diversify Treatment Options and Drive Strong Growth

1.2 List of Figures

Figure 1: Epidemiology Patterns for Atopic Dermatitis (Million), 2015-2022 15

Figure 2: Epidemiology Patterns for Acne Vulgaris (Million), 2015-2022 16

Figure 3: Epidemiology Patterns for Psoriasis (Million), 2015-2022 17

Figure 4: Dermatology, Global, Key Marketed Products and Approved Indications, 2015 24

Figure 5: Dermatology Therapeutics Market, Global, Annual Revenue for Humira ($bn), 2006-2022 26

Figure 6: Dermatology Therapeutics Market, Global, Annual Revenue for Remicade ($bn), 2006-2022 27

Figure 7: Dermatology Therapeutics Market, Global, Annual Revenue for Enbrel ($bn), 2006-2022 29

Figure 8: Dermatology Therapeutics Market, Global, Annual Revenue for Stelara ($bn), 2010-2022 30

Figure 9: Dermatology Therapeutics Market, Global, Annual Revenue for Neoral ($m), 2006-2022 32

Figure 10: Dermatology Therapeutics Market, Global, Annual Revenue for Protopic ($m), 2006-2022 33

Figure 11: Dermatology Therapeutics Market, Global, Overall Pharmaceutical Industry Pipeline by Therapy Area, 2016 38

Figure 12: Dermatology Therapeutics Market, Global, Pipeline for Dermatology by Stage of Development, Molecule Type and Program Type, 2016 40

Figure 13: Dermatology Therapeutics Market, Global, Pipeline for Key Dermatology Indications by Stage of Development, 2016 41

Figure 14: Dermatology Therapeutics Market, Global, Pipeline for Key Dermatology Indications by Molecule Type, 2016 42

Figure 15: Dermatology Therapeutics Market, Global, Pipeline for Dermatology by Molecular Target, 2016 43

Figure 16: Dermatology Therapeutics Market, Global, Pipeline for Key Dermatology Indications by Molecular Target, 2016 44

Figure 17: Dermatology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development (%), 2006-2016 45

Figure 18: Dermatology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Indication (%), 2006-2016 46

Figure 19: Dermatology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Molecule Type (%), 2006-2016 47

Figure 20: Dermatology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Molecular Target (%), 2006-2016 48

Figure 21: Dermatology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development (months), 2006-2016 49

Figure 22: Dermatology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Indication (months), 2006-2016 50

Figure 23: Dermatology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Molecule Type (months), 2006-2016 51

Figure 24: Dermatology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Molecular Target (months), 2006-2016 52

Figure 25: Dermatology Therapeutics Market, Global, Clinical Trial Size by Stage of Development (patients), 2006-2016 53

Figure 26: Dermatology Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Indication (participants), 2006-2016 54

Figure 27: Dermatology Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Molecule Type (participants), 2006-2016 55

Figure 28: Dermatology Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Molecular Target (participants), 2006-2016 56

Figure 29: Dermatology Therapeutics Market, Global, Clinical Program Size by Stage of Development (months), 2006-2016 57

Figure 30: Dermatology Therapeutics Market, Global, Clinical Program Size by Stage of Development and Indication (participants), 2006-2016 58

Figure 31: Dermatology Therapeutics Market, Global, Clinical Program Size by Stage of Development and Molecule Type (participants), 2006-2016 59

Figure 32: Dermatology Therapeutics Market, Global, Clinical Program Size by Stage of Development and Molecular Target (participants), 2006-2016 60

Figure 33: Dermatology Global, Market Size ($bn), 2015-2022 62

Figure 34: Dermatology Global, Annual Revenue Forecast for Key Products ($bn), 2015-2022 64

Figure 35: Dermatology, Global, Annual Revenue Forecast for Tumor Necrosis Factor-Alpha Inhibitors ($bn), 2015-2022 66

Figure 36: Dermatology, Global, Annual Revenue Forecast for Interleukin Inhibitors ($bn), 2015-2022 67

Figure 37: Dermatology, Global, Annual Revenue Forecast for Calcineurin Inhibitors ($bn), 2015-2022 68

Figure 38: Dermatology, Global, Annual Revenue Forecast for Glucocorticosteroids ($m), 2015-2022 69

Figure 39: Dermatology, Global, Annual Revenue Forecast for Phosphodiesterase 4 inhibitors ($bn), 2015-2022 69

Figure 40: Dermatology Therapeutics Market, Global, Forecast Market Share by Company (%), 2015-2022 72

Figure 41: Dermatology, Global, Companies by Compound Annual Growth Rate (%), 2015-2022 73

Figure 42: Dermatology, Global, Revenues by Product Type, 2015-2022 74

Figure 43: Dermatology, Global, Johnson & Johnson Annual Revenue Forecast ($bn), 2015-2022 75

Figure 44: Dermatology, Global, AbbVie Annual Revenue Forecast ($bn), 2015-2022 76

Figure 45: Dermatology, Global, Amgen Annual Revenue Forecast ($bn), 2015-2022 77

Figure 46: Dermatology, Global, Novartis Annual Revenue Forecast ($bn), 2015-2022 78

Figure 47: Dermatology, Global, Roche Annual Revenue Forecast ($bn), 2015-2022 79

Figure 48: Dermatology, Global, Merck Annual Revenue Forecast ($bn), 2015-2022 80

Figure 49: Dermatology Therapeutics Market, Global, Revenue Forecast for ABP-501 ($m), 2015-2022 81

Figure 50: Dermatology Therapeutics Market, Global, Revenue Forecast for ixekizumab ($m), 2016-2022 82

Figure 51: Dermatology Therapeutics Market, Global, Revenue Forecast for dupilumab ($m), 2016-2022 83

Figure 52: Dermatology Therapeutics Market, Global, Revenue Forecast for AN-2728 ($m), 2016-2022 84

Figure 53: Dermatology Therapeutics Market, Global, Revenue Forecast for AMG-827 ($m), 2016-2022 85

Figure 54: Dermatology Therapeutics Market, Global, Revenue Forecast for guselkumab ($m), 2016-2022 86

Figure 55: Dermatology Therapeutics Market, Global, Cluster by Growth and Market Share, 2015-2022 88

Figure 56: Dermatology, Global, Companies by Type, 2016 90

Figure 57: Dermatology, Global, Pipeline, High-Activity and Late-Stage Developers by Level of Dermatology Specialization, 2016 91

Figure 58: Dermatology, Global, Proportion of Total Company Revenue Attributed to Dermatology, 2015-2022 92

Figure 59: Dermatology, Global, Licensing Deals, 2006-2016 94

Figure 60: Dermatology, Global, Licensing Deals by Indication, 2006-2016 95

Figure 61: Dermatology, Global, Licensing Deals, 2006-2016 96

Figure 62: Dermatology, Global, Licensing Deals by Molecule Type and Mechanism of Action, 2006-2016 97

Figure 63: Dermatology, Global, Co-development Deals, 2006-2016 99

Figure 64: Dermatology, Global, Co-development Deals by Indication, 2006-2016 100

Figure 65: Dermatology, Global, Co-development Deals, 2006-2016 101

Figure 66: Dermatology, Global, Co-development Deals by Molecule Type and Mechanism of Action, 2006-2016 102

Additional Details

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GBI Research

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Number of Pages

144

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PDF

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