Diabetes -- KOL Insight and Consensus Outlook Modules
Published by FirstWord Pharma: 01 May 2014 | 118 | In Stock
The medium term: battle lines are drawn
The fundamental drivers of the global diabetes market are strong and continue to fuel growth. Rising levels of obesity and disease prevalence in both established and emerging markets have seen the sector return a 5 year compound annual growth rate (CAGR) of 12% over to reach US.9 billion in 2012. It is estimated that 347 million people have the disease – 90% of whom are Type II diabetes sufferers – and this figure could almost double by 2030.
The big four companies in diabetes - Novo Nordisk, Sanofi, Eli Lilly and Merck – are locked in a battle of supremacy which is set to continue over the medium term. While Novo Nordisk currently leads the pack, Sanofi is close behind. With Novo Nordisk’s approval of Tresiba (insulin degedec) stalled in the US over safety concerns, Sanofi latest version of Lantus U300 (insulin glargine)) could capitalise. Bristol Myers-Squibb and AstraZeneca are just two of the other players set to increase their sales significantly in this busy market place by 2017.
The diabetes market will continue on an upward trajectory, and an estimated 5 year CAGR of 11 percent will see the sector top US billion – the question is which companies will have a slice to this market, and how big will it be?
What’s in the pipeline?
Finding market voice for new products in diabetes depends critically on price and differentiation. Cost of treatment is already an issue and resistance can be expected from health payers if new products offer only marginal therapeutic or patient management benefits. For example, excitement about Sanofi's U300 (insulin glargine) is because it shows differentiation to Lantus with “peakless” delivery and longer duration. Eli Lilly’s weekly dose dulaglutide may offer advantages over other launched and pipeline GLP-1 products such as such as GSK’s Eperzan (albiglutide) and BMS/AZ/Amylin’s Bydureon (exanatide) but meaningful advantages need to be shown for success in the market.
What the Future Holds: is there a Game Changer on the Horizon?
Don’t expect a revolution in diabetes treatment soon. New products coming to market are essentially incremental improvements over current approaches, with better safety profiles and geared to improving patient compliance.
The real prize will be for the company that can bring a paradigm shift to the treatment of diabetes. Upsetting the status quo will require a fundamentally different approach - and some of these developments threaten the diabetes drugs manufacturers existing revenues.
Among the developments to be aware of are the threat of biosimilars, the development of an artificial pancreas 'closed loop' system, the wide implementation of which would be a doomsday development for drugs companies, and a DNA reverse vaccine for which early clinical results have shown promising results.
A Complete Ongoing Analysis of Current Trends, Future Forecasts and Landscape Modifiers
For instant access to an accurate, unbiased, qualitative review of the latest treatment trends along with a five-year quantitative diabetes market forecast look no further than FirstWord’s Therapy Trends: Diabetes. This comprehensive FirstWord research is available in two comprehensive modules:
Therapy Trends KOL Insight: Diabetes analyses the current and predicted key issues, current products and late-stage pipeline products. The report gives you qualitative, inside information from exclusive FirstWord interviews with 12 key opinion leaders (KOLs) through the following:
Key Report Features and Benefits
Expert Opinion for Real World Insights
The data and analysis in the report is enriched through the specific insights and opinions of leading clinicians working in diabetes in the US and Europe. Their views on specific drugs and treatment pathways provide a unique front line perspective from those working in clinical setting. The results of these detailed and extensive interviews are incorporated though out the text so they can be read in the context of the issue or product being discussed.
Key Quotes from the Report
“I like Janumet. I get a much more effective medication even in one pill a day using combination therapy. Janumet has this long acting glycol, so it is long acting. In early diabetes, together with lifestyle changes, I often use a combination of DPP-IV with metformin, either once or twice a day because it doesn't cause hypoglycaemia. The patients don't need to monitor their blood sugar three, four, five times a day. They don't get admitted to the hospital with hypoglycaemia so the side effects are low. So I start treating these patients with a combination therapy, like Janumet.” Dr Joel Zonszein (US)
“I think lots of people use Kombiglyze because it improves compliance so it makes sense. In the therapeutic armamentarium it’s the only real once daily combination.” Professor Sonal Singh (US)
“In terms of efficacy, side effects, convenience and device, Victoza is the preferred GLP-1. If I look at the new-starts, probably 60 percent of people are going for the Victoza” Dr Carol Wysham (US)
“The prevention of hypoglycaemia is a very important aim for the classical drugs and an unmet need. We should be searching for alternatives to insulin.” Professor Baptist Gallwitz (EU)
“I am not too optimistic that you can improve DPP-IV inhibitors to be more efficacious. You may well be able to improve GLP-1 agonists to have more efficacious drugs that have less side effects based on the variety within the class that we have seen until now. I think that the pharmaceutical industry as a whole is a little bit running out of ideas, so we really need to identify good targets.” Professor Michael Nauck (EU)
“I think if someone came up with a reasonably well-tolerated drug that helped you lose weight [and] that you only had to take once a month or once a year? Everyone would be on that. US Key Opinion Leader
“Our local insurance company have taken all of what they consider tier 3 drugs, and they include all the GLP-1 agents including the DPP-IV inhibitors, and just put them on a 50-percent co-pay. Fifty percent of a lot of money is still a lot of money.” Dr Carol Wysham (US)
KOL Insights -- Key Topics
Use this detailed report and powerful interactive Excel spreadsheet to compare and contrast companies and products now and in the future. Therapy Trends Consensus Outlook: Diabetes includes the following comprehensive resources:
Use Consensus Outlook to:
Content Highlights and Products Covered:
Table of Contents
for Diabetes -- KOL Insight and Consensus Outlook Modules
Contents Consensus Outlook
1.FirstWord Analysis Highlights
4.Key Diabetes Developers
5.Diabetes Class Dynamics
6.Lantus (insulin glargine; Sanofi) forecast
7.Levemir (insulin detemir; Novo Nordisk) forecast
8.Tresiba (insulin degludec; Novo Nordisk) forecast
9.Ryzodeg (degludecPlus; Novo Nordisk) forecast
10.NovoRapid/NovoLog (insulin aspart; Novo Nordisk) forecast
11.Humalog (insulin lispro; Eli Lilly) forecast
12.Apidra (insulin glulisine; Sanofi) forecast
13.NovoMix/NovoLog Mix (insulin aspart + insulin aspart protamine; Novo Nordisk) forecast
14.Januvia franchise (sitagliptin; Merck & Co) forecast
15.Galvus franchise (vildagliptin; Novartis) forecast
16.Onglyza franchise (saxagliptin; Bristol-Myers Squibb/AstraZeneca/ Otsuka) forecast
17.Nesina franchise (alogliptin; Takeda) forecast
18.Tradjenta franchise (linagliptin; Boehringer Ingelheim/Eli Lilly) forecast
19.Byetta (exenatide; Bristol-Myers Squibb/AstraZeneca/Amylin) forecast
20.Bydureon (exenatide once-weekly; Bristol-Myers Squibb/AstraZeneca/ Amylin) forecast
21.Victoza (liraglutide; Novo Nordisk) forecast
22.Lyxumia (lixisenatide; Sanofi) forecast
23.Invokana (canagliflozin; Johnson & Johnson/Mitsubishi Tanabe) forecast
24.Forxiga (dapagliflozin; Bristol-Myers Squibb/AstraZeneca) forecast
25.Actos (pioglitazone; Takeda) forecast
26.U300 (insulin glargine; Sanofi) forecast
27.LY2605541 (insulin peglispro; Eli Lilly) forecast
28.LY2963016 (biosimilar insulin glargine; Eli Lilly/Boehringer Ingelheim) forecast
29.IDeglira (liraglutide + insulin degludec; Novo Nordisk) forecast
30.Afrezza (Technosphere Insulin; MannKind Corporation) forecast
31.FIAsp (insulin aspart; Novo Nordisk) forecast
32.Eperzan (albiglutide; GlaxoSmithKline/Human Genome Sciences) forecast
33.LY2189265 (dulaglutide; Eli Lilly) forecast
34.BI-10773 (empagliflozin; Boehringer Ingelheim/Eli Lilly) forecast
4.Current diabetes marketplace
5.7.Complications of diabetes
5.10.Current treatment landscape
5.11.Reimbursement of key diabetes brands
6.Current marketed therapies
6.4.Dipeptidyl Peptidase-IV (DPP-IV) inhibitors
6.5.Glucagon-like peptide-1 (GLP-1) agonists/analogues
6.6.Sodium-glucose co-transporter-2 (SGLT-2) inhibitors
6.8.Other non-insulin anti-diabetics
7.1.Pipeline basal insulins
7.2.Pipeline prandial insulins
7.3.Pipeline dipeptidyl peptidase-IV (DPP-IV) inhibitors
7.4.Pipeline glucagon-like peptide-1 (GLP-1) agonists/analogues
7.5.Pipeline sodium-glucose co-transporter 2 (SGLT-2) inhibitors
7.6.Other pipeline non-insulin anti-diabetics
8.1.Unmet needs in type 1 diabetes
8.2.Unmet needs in type 2 diabetes
8.3.Current treatment algorithm- Type2 diabetes
8.4.Future treatment algorithm
9.Future developments in Diabetes
9.1.Biosimilar insulin commercial threat limited
9.2.Continuous glucose monitoring and closed loop systems
9.3.Transplantation or regeneration of beta-cells
9.4.Targeting immune response and inflammation
Number of Pages
|Title||Date Published||Price from||More Details|
|FirstView Barriers – An Analysis of Market Barriers in Type 2 Diabetes (US)|
IntroductionWhat environmental market barriers are influencing the Type 2 Diabetes (T2DM) market? F...
|20 Apr 2015 by FirstWord Pharma||USD $4,995||More Info|
|FirstView Barriers – An Analysis of Market Barriers in Type 2 Diabetes (EU5)|
IntroductionWhat market barriers are influencing the Type 2 Diabetes (T2DM) market? From price to a...
|20 Apr 2015 by FirstWord Pharma||USD $4,995||More Info|
|Physician Views: Can Intarcia's implantable GLP-1 treatment revolutionise the diabetes market?|
Scope Intarcia has previously suggested that it is the highest-valued privately owned biotech compan...
|20 Apr 2015 by FirstWord Pharma||USD $695||More Info|
|Physician Views: How do endocrinologists value diabetes-focused medical affairs teams – what could they be doing better?|
Scope Medical affairs teams are playing an increasingly critical role for pharmaceutical manufacture...
|08 Dec 2014 by FirstWord Pharma||USD $695||More Info|
|Physician Views: US formulary management in diabetes – are endocrinologists impressed?|
Scope Pricing pressure exerted by US pharmacy benefit managers (PBMs) and managed care organisations...
|12 Aug 2014 by FirstWord Pharma||USD $695||More Info|
|Physician Views: Five key diabetes market questions ahead of ADA 2014|
Scope This year's annual meeting of the American Diabetes Association (ADA) – which will take place ...
|13 Jun 2014 by FirstWord Pharma||USD $695||More Info|
|Physician Views: Which diabetes company does the best marketing job? What is key for companies launching products?|
ScopeThe importance of marketing is increasingly coming to the fore as diabetes-focused companies ba...
|01 Aug 2013 by FirstWord Pharma||USD $695||More Info|
|Physician Views: Post ADA view on key diabetes market developments|
ScopeLast week’s American Diabetes Association (ADA) meeting provided further evidence that the diab...
|01 Jul 2013 by FirstWord Pharma||USD $695||More Info|
|Physician Views: Key developments in the European diabetes market - will endocrinologists embrace Tresiba and Forxiga? – both rejected by the FDA|
ScopeEuropean-based endocrinologists are currently getting to grips with two new products that have ...
|01 Jul 2013 by FirstWord Pharma||USD $695||More Info|
|Physician Views: Recent developments in US diabetes market – impact of safety concerns & emergence of SGLT-2 drug class|
ScopeWith the diabetes market an important therapeutic area for a host of pharmaceutical manufacture...
|01 Jun 2013 by FirstWord Pharma||USD $695||More Info|
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