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Biochips - technologies,markets and companies [Report Updated: 08-09-2017]

Published by Jain PharmaBiotech: 08 Sep 2017 | 117647 | In Stock

Introduction

Summary

This report is an analysis of biochip/microarray markets based on technologies and applications. The report starts with a description of technologies as a basis for estimation of markets. Technologies include array comparative genomic hybridization (CGH), copy number variation (CNV), DNA methylation, ChIP-Chip, RNA splice variants, and microRNA. Separate chapters are devoted to protein biochips/microarrays, microfluidics and nanobiotechnology-based nano-arrays.

Various applications of biochips and microarrays are described throughout the report. Areas of application such as point-of-care, genetic screening, cancer, and diagnosis of infections are included. Separate chapters are devoted to applications in drug discovery and development as well as personalized medicine

The report provides current share of each segment: market size in 2015 and projected value for the years 2020 and 2025. Gene expression has the largest share and is an established market. Share of microarray technologies in other areas will grow with the maximum growth in RNA splice variants followed by epigenetics. The growth in protein microarrays is somewhat less, partly because it is more mature than the other submarkets and has already shown considerable growth in the past. Impact of next generation sequencing on segments of microarray markets is identified. Customer requirements and unmet needs are described. Markets are also analyzed according to geographical areas.

Brief profiles of companies involved in biochip/microarray technologies are provided. Currently selected 92 companies are included along with listing of 120 collaborations between companies. The text is supplemented by 21 tables, 11 figures and 140 references to literature.

Table of Contents
for Biochips - technologies,markets and companies [Report Updated: 08-09-2017]

  • Table of contents

    Introduction to Biochips and Microarrays

    Biochip and MicroarrayTechnologies

    Microfluidics-based Biochips and Microarrays

    Protein Biochips

    Nanotechnology-based Biochips and Microarrays

    Biochips & Microarrays for Epigenetics

    Applications of Microarrays in Drug Discovery & Development

    Biochip for Biomarkers, Molecular Diagnostics & Personalized Medicine

    Markets for Biochips & Microarrays

    Companies

    References

    0. Executive Summary . 10

    1. Introduction 12

    Definitions of biochips/microarray .12

    Terms used for biochips .12

    Historical aspects of biochip/microarray technology 13

    Relation of microarrays to other technologies .14

    Applications of biochips/microarrays .15

    Advantages of biochips/microarrays 15

    2. Biochip and Microarray Technologies . 16

    Introduction .16

    Nucleic acid amplification and microarrays 16

    PCR on a chip . 16

    Fast PCR biochip . 16

    Multiplex microarray-enhanced PCR for DNA analysis 17

    Universal DNA microarray combining PCR and ligase detection reaction 17

    NASBA combined with microarray . 18

    Rolling circle amplification on microarrays 18

    LiquiChip-RCAT . 18

    Multiplexed Molecular Profiling18

    Genomewide association scans19

    Whole genome microarrays .19

    GeneChip Human Genome Arrays . 20

    Arrayit's® H25K . 21

    Transposon insertion site profiling chip 21

    Standardizing the microarrays.21

    Optical Mapping 22

    Imaging technologies used for detection in biochips/microarray 22

    Fluorescence and chemiluminescence. 23

    MALDI-MS imaging and tissue microarrays . 23

    Surface plasmon resonance technology for microarrays 24

    Microarray imaging systems 25

    Vidia™ Microarray Imaging Systems . 25

    GenePix 4100A Microarray Scanner 26

    Tecan LS Reloaded™ . 26

    Microarrays based on detection by physico-chemical methods 27

    Electrical biochips . 27

    Photoelectrochemical synthesis of DNA microarrays . 27

    Microchip capillary electrophoresis 28

    Strand displacement amplification on a biochip 28

    Biosensor technologies for biochips 28

    DNA-based biosensors 29

    Arrayed Imaging Reflectometry 29

    Phototransistor biochip biosensor 30

    Applications of biosensor biochips . 30

    Biosensors in food safety . 31

    Cholesterol biosensor 31

    Glucose biosensors 32

    Microarrays for cytogenetics 32

    Comparative genomic hybridization . 32

    Array-based CGH 33

    NimbleGen CGH arrays 34

    Single-cell array CGH 34

    Regulatory requirements for array CGH . 34

    Agilent CGH+SNP microarray platform . 35

    SignatureChip® 35

    Tissue microarrays .35

    Pathology tissue-ChIP . 36

    Carbohydrate microarrays .36

    RNA profiling 36

    RNA splice variants . 37

    RIP-Chip . 37

    miRNAs 38

    Microarrays for miRNAs . 38

    Microarrays vs qPCR for measuring miRNAs . 39

    Quantitative analysis of miRNAs in tissue microarrays by ISH . 40

    - 4 -

    Exon microarrays 40

    Microarrays & DNA sequencing41

    Microarray-based emerging DNA sequencing technologies 41

    Exome sequencing for study of human variation 42

    High-throughput array-based resequencing 42

    Sequencing by hybridization 42

    SOLiD-System based ChIP-Sequencing 43

    Next generation sequencing vs microarrays for expression profiling . 44

    Microarrays for synthetic biology 44

    Arrayit microarray platform for synthetic biology . 44

    Microarray-based gene synthesis 45

    Magnetophoretic array-based cell sorting for further studies . 45

    3. Microfluidics-based Biochips and Microarrays 46

    Introduction .46

    Fish-on-chip 46

    Lab-on-a-chip .47

    LabChip 47

    LabCD 47

    Lab-on-a-brain . 48

    Lab-on-a-chip multiplex immunoassay . 48

    Micronics' microfluidic technology 48

    Rheonix CARD technology . 49

    Microfluidic chips/arrays using PCR .49

    Digital PCR Array 49

    Digital PCR on a SlipChip 49

    Microfluidic automated DNA analysis using PCR . 50

    Microfluidic single-cell RT-qPCR on a chip. 50

    Microfluidic chips integrated with RCAT 50

    Microfluidic chips integrated with PET 51

    Molecular diagnostic applications of microfluidic biochips 51

    Biochips/microfluidics for detection of circulating tumor cells 51

    CEE (cell enrichment and extraction) technology. 51

    Cluster-Chip for capturing CTCs . 51

    CTChip™ . 52

    DNA nanospheres for isolation of CTCs 52

    Herringbone-chip for detection of CTCs 52

    Lab-on-chip for the isolation and detection of CTCs 53

    Microfluidic devices for analyzing blood of pediatric and neonatal patients. 53

    Microfluidic PepArray™ for in situ synthesis of peptides .53

    Integrated microfluids platform for biomolecular interactions 54

    Companies developing microfluidic technologies .54

    4. Protein Biochips . 56

    Introduction .56

    Protein biochip technologies 56

    Protein microarrays 56

    Affinity proteomics /antibody microarrays 57

    Applications of antibody microarrays 57

    Antibody microarrays for diagnosis of cancer 58

    Discovery of biomarkers by MAb microarray profiling 59

    Aptamer-based protein biochip 59

    High-density protein microarrays 59

    HPLC-Chip for protein identification . 60

    2D displacement chromatography using HPLC Chip 60

    LabChip for protein analysis 60

    MALDI-MS imaging and protein microarrays 61

    Multiplexed Protein Profiling on Microarrays . 61

    Peptide microarrays 62

    ProteinChip 62

    Protein chips for antigen-antibody interactions molecular diagnostics . 64

    Proteomic pattern analysis 64

    Reverse phase protein microarrays . 64

    Single molecule array . 65

    TRINECTIN proteome chip . 65

    New developments in protein chips/microarrays 66

    Microfluidic devices for proteomics-based diagnostics .66

    Viral protein chip 66

    Use of microarray technologies in human protein atlas initiative 67

    Applications of protein biochip/microarrays 67

    Applications of peptide microarrays . 68

    - 5 -

    Biosensor protein chip 69

    Nucleic Acid Programmable Protein Array. 70

    Proteome Identification Kit 70

    Protein nanobiochip for diagnosis 71

    Proteomic chip for profiling signaling pathways in single tumor cells . 71

    Protein biochips/microarrays for personalized medicine 71

    Companies involved protein biochips/microarrays 72

    5. Nanobiotechnology-based Biochips & Microarrays . 76

    Introduction .76

    Nanotechnology-based biochips .76

    Fullerene photodetectors for chemiluminescence detection on microfluidic chip . 76

    Nanotechnology on a chip . 76

    NanoChip® Electronic Microarray 77

    Silver nanorod array for on-chip detection of microbes and chemicals 77

    Verigene System . 78

    Use of nanotechnology in microfluidics .78

    Construction of nanofluidic channels 79

    NanoAnalyzer® chip 79

    Nanoscale flow visualization 80

    Moving (levitation) of nanofluidic drops with physical forces . 80

    Electrochemical nanofluid injection 81

    Nanofluidics on nanopatterned surfaces . 81

    Nano-interface in a microfluidic chip 81

    Nanofluidic channels for study of DNA . 82

    Nanoarrays 82

    Dip Pen Nanolithography for nanoarrays 83

    NanoPro™ System 84

    Nanosensors .85

    Biochips with nanosensors 85

    Peptide nucleic acid nanobiosensor arrays 85

    Cantilever arrays 86

    Nanotechnology-based protein biochips/microarrays 86

    AFM for immobilization of biomolecules in high-density nanoarrays 86

    Nanoparticle protein chip 87

    Protein biochips based on fluorescence planar wave guide technology 87

    Self-assembling protein nanoarrays . 88

    Diagnostic applications of nanobiochips .88

    Nanofluidic devices to detect a single molecule of DNA 88

    Nanochip/biosensor for detection of circulating cancer cells 88

    6. Biochips & Microarrays for Epigenetics 90

    Introduction .90

    Epigenomic technologies .90

    Epigenomics Digital Phenotype 90

    Global methylation analysis . 91

    Illumina’s assays for analysis of methylation sites 91

    GenomicTree’s MDScan technology . 91

    Orion’s MethylScope® technology . 91

    ChIP-chip 91

    Microarray for immunogenetic testing 92

    Applications for study of DNA methylation 92

    7. Applications of Microarrays in Drug Discovery & Development . 94

    Introduction .94

    Drug discovery 94

    Finding lead compounds . 94

    High-throughput cDNA microarrays . 94

    Use of gene expression data to find new drug targets . 95

    Investigation of the mechanism of drug action 95

    Cellular microarrays 95

    Peptide microarrays for high-throughput screening 96

    Biochips for toxicology studies . 96

    Gene expression studies for toxicology using microarrays . 96

    MetaChip/Datachip 96

    Testing drugs in organ-on-a-chip microdevices 97

    ADME-on-a-chip. 97

    Brain cancer chip for personalized drug screening 97

    Liver-on-a-chip 98

    Lung-on-a-chip 98

    Stem cells differentiation on a chip for testing response to drugs 99

    - 6 -

    SmartChip for cancer drug discovery . 99

    Drug development 99

    Use of microarrays in clinical trials 99

    Reverse phase protein microarrays . 99

    Controlled-release microchip for drug delivery 100

    Implanted chips for drug delivery 100

    Lab-on-a-chip for drug delivery 100

    Pharmacy-on-a-chip . 100

    8. Biochips for Biomarkers, Molecular Diagnostics & Personalized

    Medicine . 102

    Introduction .102

    Microarrays with integrated PCR 102

    AmpliChip CYP450. 103

    AmpliChip P53 as companion diagnostic for cancer . 104

    Infinity System . 104

    In-Check Lab-on-Chip . 104

    Biochips for POC diagnosis 105

    Triage protein chip 105

    Lab-on-a-chip . 105

    POC salivary diagnostic biochip . 106

    POC microarray for detection of circulating microRNA biomarkers 106

    Application of microarrays for discovery of biomarkers 107

    Gene expression microarray data as a source of protein biomarkers . 107

    Peptide array technology for detection of biomarkers 107

    Protein microarrays for discovery of biomarkers . 107

    QPDx® BioChips for biomarkers . 108

    Tissue microarrays for study of biomarkers . 108

    Biochip and microarray-based detection of SNPs.109

    Affymetrix Variation Detection Arrays 109

    Biochip combining BeadArray and ZipCode technologies 109

    NanoChip for detection of SNPs 109

    SNP genotyping by MassARRAY 109

    SNP-IT primer-extension technology . 110

    Copy number variations in the human genome 110

    Agilent microarrays 111

    Affymetrix microarrays . 112

    Infinium’s CNV and SNP lines 113

    HD Huma
    660W-Quad BeadChip . 113

    Roche NimbleGen’s CGH and CNV product line . 113

    TaqMan® Copy Number Assays 114

    Innovations in CNV and CGH microarrays 114

    Bioinformatic tools for analysis of CNV data . 114

    Applications of biochip technology in personalized medicine .115

    Commercial development of biochip technologies for diagnostics .116

    9. Markets 118

    Introduction .118

    Methods for estimation of markets .118

    Microarray markets.118

    Market share of microfluidics-based microarrays 119

    Gene expression microarray markets . 119

    Array CGH markets 119

    CNV markets 120

    Markets for RNA splice variants 120

    Markets for imaging technologies used in biochips/microarrays 120

    Markets for microarray relevant to miRNA .121

    Epigenetic markets .121

    ChIP-Chip 121

    Markets for protein microarrays .121

    Role of scientists’ attitudes on the evolution of protein microarray markets 122

    Market share of microarray technology in protein biomarkers . 122

    Geographical distribution of microarray markets 122

    Currents trends .123

    Types of arrays used 123

    Tiling array . 123

    Exon array 124

    Reaction specifics 124

    Pre-amplification use . 124

    Reagents from array vendor or other sources . 124

    Dual versus single color array preference . 125

    - 7 -

    Oligo versus BAC preference . 125

    Cost per sample or cost per array . 125

    Preference for single versus multiplex sample arrays . 126

    Current and future throughput in samples per week 126

    Use in niche markets 126

    Diagnostics . 126

    Drug discovery 127

    Therapeutics . 127

    Research . 128

    Screening assays versus whole genome aCGH . 128

    Effect of next generation sequencing on microarray markets 129

    Impact of next generation sequencing on microarray markets for diagnostics . 129

    Impact of next gen sequencing on microarray markets for drug discovery 129

    Resequencing 130

    RNA profiling . 130

    Transcriptome sequencing for mRNA Expression 130

    Applications of next generation sequencing in basic research 131

    Mapping and sequencing of structural variation from human genomes 131

    Identifying protein-coding genes in genomic sequences 131

    Applications in clinically relevant areas 132

    Genetic disorders 132

    Cancer research 133

    Management of HIV/AIDS 134

    Customer requirements and unmet needs .134

    Concluding remarks on microarray markets 135

    Future of biochip technology for molecular diagnostics . 135

    Impact of next generation sequencing on microarray markets in the future 135

    Effect on CNV market 135

    Effect on RNA profiling . 135

    Screening samples 136

    10. Companies . 138

    Profiles of companies .138

    Collaborations .249

    11. References . 254

List Of Tables
in Biochips - technologies,markets and companies [Report Updated: 08-09-2017]

Tables

Table 1-1: Various terms used for biochips, microarrays and microfluidics .......... 12

Table 1-2: Historical landmarks relevant to the development of biochip technology............. 13

Table 1-3: Applications of microarrays 15

Table 2-1: Companies developing whole genome chips/microarrays.... 19

Table 2-2: Microarray imaging systems ............. 25

Table 2-3: Applications of biosensor biochips in healthcare . 31

Table 2-4: Microarray/biochip-based technologies for cytogenetics ..... 32

Table 2-5: Companies developing whole genome chips/microarrays.... 41

Table 2-6: ChIP detection platforms for sequencing ........... 43

Table 3-1: Companies developing microfluidic technologies. 54

Table 4-1: Applications of protein biochips/microarrays ...... 67

Table 4-2: Applications of peptide microarrays ... 68

Table 4-3: Companies involved in peptide microarrays ....... 69

Table 4-4: Selected companies involved in protein biochip/microarray technology .............. 72

Table 5-1: Companies with nanoarray and nanofluidic technologies .... 83

Table 8-1: Applications of biochip technology relevant to personalized medicine 115

Table 8-2: Companies involved in biochips for molecular diagnostics. 117

Table 9-1: Growth of markets for biochip/microarray technologies from 2015 to 2025 ...... 118

Table 9-2: Geographical distribution of biochip/microarray markets 2015-2025. 123

Table 9-3: Global markets for sequencing services according to applications ..... 129

Table 10-1: Collaborations .............. 249

List Of Figures, Charts and Diagrams
in Biochips - technologies,markets and companies [Report Updated: 08-09-2017]

Figures

Figure 1-1: Relation of biochips/microarrays to other technologies and applications ............ 14

Figure 2-1: Affymetrix GeneChip technology ...... 20

Figure 2-2: Surface plasma resonance (SPR)...... 24

Figure 2-3: Basic principle of a biosensor........... 29

Figure 2-4: Principle of Arrayed Imaging Reflectometry ...... 30

Figure 2-5: Construction of SOLiD fragment library using DNA enrichment by ChIP............. 43

Figure 4-1: ProteinChip System......... 63

Figure 5-1: Schematic representation of Dip Pen Nanolithography (DPN) ............ 83

Figure 8-1: Role of biochip/microarray technology in personalized medicine ..... 102

Figure 8-2: Role of CYP450 genotyping in development of personalized medicine ............. 104

Figure 8-3: Application of biochips/microarrays in personalized medicine.......... 116

Additional Details

Publisher

Jain PharmaBiotech

Publisher Information

Jain PharmaBiotech was formed by Prof. Dr. K.K.Jain in 1996 for basic as well as clinical research and to provide consulting services for the biopharmaceutical industries.

Reference

117647 |

Number of Pages

267

Report Format

PDF

Jain PharmaBiotech Reports

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This report is published by Jain PharmaBiotech

Jain PharmaBiotech was formed by Prof. Dr. K.K.Jain in 1996 for basic as well as clinical research and to provide consulting services for the biopharmaceutical industries.

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