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Proteomics - Technologies, Markets and Companies
[Report Updated: 08-09-2017]

Published by Jain PharmaBiotech: 08 Sep 2017 | 117629 | In Stock
Related Topics: Protein , Proteomics

Introduction

Summary

This report describes and evaluates the proteomic technologies that will play an important role in drug discovery, molecular diagnostics and practice of medicine in the post-genomic era - the first decade of the 21st century. Most commonly used technologies are 2D gel electrophoresis for protein separation and analysis of proteins by mass spectrometry. Microanalytical protein characterization with multidimentional liquid chromatography/mass spectrometry improves the throughput and reliability of peptide mapping. Matrix-Assisted Laser Desorption Mass Spectrometry (MALDI-MS) has become a widely used method for determination of biomolecules including peptides, proteins. Functional proteomics technologies include yeast two-hybrid system for studying protein- protein interactions. Establishing a proteomics platform in the industrial setting initially requires implementation of a series of robotic systems to allow a high-throughput approach for analysis and identification of differences observed on 2D electrophoresis gels. Protein chips are also proving to be useful. Proteomic technologies are now being integrated into the drug discovery process as complimentary to genomic approaches. Toxicoproteomics, i.e. the evaluation of protein expression for understanding of toxic events, is an important application of proteomics in preclincial drug safety. Use of bioinformatics is essential for analyzing the massive amount of data generated from both genomics and proteomics.

Proteomics is providing a better understanding of pathomechanisms of human diseases. Analysis of different levels of gene expression in healthy and diseased tissues by proteomic approaches is as important as the detection of mutations and polymorphisms at the genomic level and may be of more value in designing a rational therapy. Protein distribution / characterization in body tissues and fluids, in health as well as in disease, is the basis of the use of proteomic technologies for molecular diagnostics. Proteomics will play an important role in medicine of the future which will be personalized and will combine diagnostics with therapeutics. Important areas of application include cancer (oncoproteomics) and neurological disorders (neuroproteomics). The text is supplemented with 44 tables, 28 figures and over 500 selected references from the literature.

The number of companies involved in proteomics has increased remarkably during the past few years. More than 300 companies have been identified to be involved in proteomics and 223 of these are profiled in the report with 456 collaborations.

The markets for proteomic technologies are difficult to estimate as they are not distinct but overlap with those of genomics, gene expression, high throughput screening, drug discovery and molecular diagnostics. Markets for proteomic technologies are analyzed for the year 2015 and are projected to years 2020 and 2025. The largest expansion will be in bioinformatics and protein biochip technologies. Important areas of application are cancer and neurological disorders.

Table of Contents
for Proteomics - Technologies, Markets and Companies [Report Updated: 08-09-2017]

  • Table of contents

    Part I: Technologies and Markets

    Basics of Proteomics

    Proteomic Technologies

    Protein Biochip technology

    Bioinformatics in Relation to Proteomics

    Research in Proteomics

    Pharmaceutical Applications of Proteomics

    Application of Proteomics in Healthcare

    Oncoproteomics

    Neuroproteomics

    Commercial Aspects of Proteomics

    Future of Proteomics

    References

    Part II: Companies

    Companies Involved in Developing Proteomics

List Of Tables
in Proteomics - Technologies, Markets and Companies [Report Updated: 08-09-2017]

Table 1-1: Landmarks in the evolution of proteomics ............... 19

Table 1-2: Comparison of DNA and protein .. 29

Table 1-3: Comparison of mRNA and protein 29

Table 1-4: Methods of analysis at various levels of functional genomics ................. 35

Table 2-1: Proteomics technologies ............. 41

Table 2-2: Protein separation technologies of selected companies ......................... 46

Table 2-3: Companies supplying mass spectrometry instruments.......................... 54

Table 2-4: Companies involved in cell-based protein assays ...... 76

Table 2-5: Methods used for the study of protein-protein interactions ................... 78

Table 2-6: A selection of companies involved in protein-protein interaction studies . 85

Table 2-7: Companies involved in Western blotting ................ 101

Table 2-8: Proteomic technologies used with laser capture microdissection .......... 103

Table 3-1: Applications of protein biochip technology ............... 105

Table 3-2: Selected companies involved in protein biochip/microarray technology 121

Table 4-1: Proteomic databases and other Internet sources of proteomics information ..................... 129

Table 4-2: Protein interaction databases available on the Internet ...................... 135

Table 4-3: Bioinformatic tools for proteomics from academic sources .................. 141

Table 4-4: Selected companies involved in bioinformatics for proteomics ............. 142

Table 5-1: Applications of proteomics in basic biological research ....................... 145

Table 5-2: A sampling of proteomics research projects in academic institutions .... 161

Table 6-1: Pharmaceutical applications of proteomics ............. 165

Table 6-2: Selected companies relevant to MALDI-MS for drug discovery............. 172

Table 6-3: Selected companies involved in GPCR-based drug discovery ............... 181

Table 6-4: Companies involved in drug design based on structural proteomics ..... 187

Table 6-5: Proteomic companies with high-throughput protein expression technologies .................... 194

Table 6-6: Selected companies involved in chemogenomics/chemoproteomics ..... 204

Table 6-7: Companies involved in glycoproteomic technologies 210

Table 7-1: Applications of proteomics in human healthcare ..... 223

Table 7-2: Eye disorders and proteomic approaches............... 254

Table 8-1: Large scale international oncoproteomic initiatives . 282

Table 8-2: Companies involved in applications of proteomics to oncology ............ 283

Table 9-1: Neurodegenerative diseases with underlying protein abnormality ........ 289

Table 9-2: Disease-specific proteins in the cerebrospinal fluid of patients............. 301

Table 10-1: Potential markets for proteomic technologies 2015-2025.................. 309

Table 10-2: Geographical distribution of markets for proteomic technologies 2015-2025 .................. 313

Table 11-1: Role of proteomics in personalizing strategies for cancer therapy....... 339

Table 11-1: Companies with proteomics as the main activity/service.....................4

Table 11-2: Selected companies with equipment and laboratory services for proteomics......................6

Table 11-3: Biotechnology and drug discovery companies involved in proteomics ....6

Table 11-4: Bioinformatics companies involved in proteomics....8

Table 11-5: Biopharmaeutical companies with in-house proteomics technology .......9

Table 11-6: Major players in proteomics.....9

Table 10-7: Selected collaborations of companies in the area of proteomics.........249

List Of Figures, Charts and Diagrams
in Proteomics - Technologies, Markets and Companies [Report Updated: 08-09-2017]

Figures

Figure 1-1: A schematic miRNA pathway ..... 22

Figure 1-2: Relationship of DNA, RNA and protein in the cell....... 30

Figure 1-3: Protein production pathway from gene expression to functional protein with controls......... 33

Figure 1-4: Parallels between functional genomics and proteomics........................ 33

Figure 2-1: Proteomics: flow from sample preparation to characterization.............. 42

Figure 2-2: The central role of spectrometry in proteomics ....... 49

Figure 2-3: Electrospray ionization (ESI) ..... 50

Figure 2-4: Matrix-Assisted Laser Desorption/Ionization (MALDI) .......................... 52

Figure 2-5: Scheme of bio-bar-code assay ... 71

Figure 2-6: A diagrammatic presentation of yeast 2-hybrid system ....................... 84

Figure 3-1: ProteinChip System ................ 107

Figure 3-2: Surface plasma resonance (SPR)......................... 118

Figure 4-1: Role of bioinformatics in integrating genomic/proteomic-based drug discovery ............... 128

Figure 4-2: Bottom-up and top-down approaches for protein sequencing ............. 139

Figure 6-1: Drug discovery process ........... 166

Figure 6-2: Regulatory changes induced by drugs and implemented at the proteins level.................. 169

Figure 6-3: Relation of proteome to genome, diseases and drugs ....................... 170

Figure 6-4: The mTOR pathways............... 184

Figure 6-5: Steps in shotgun proteomics.... 202

Figure 6-6: Chemogenomic approach to drug discovery (3-Dimensional Pharmaceuticals) ................ 203

Figure 8-1: Relation of oncoproteomics to other technologies .. 261

Figure 9-1: A scheme of proteomics applications in CNS drug discovery and development ................ 306

Figure 10-1: Types of companies involved in proteomics collaborations ............... 317

Figure 10-2: Types of collaborations: R & D, licensing or marketing .................... 318

Figure 10-3: Proteomics collaborations according to application areas ................. 318

Figure 10-4: Proteomics collaborations according to technologies ....................... 319

Figure 10-5: Unmet needs in proteomics ... 324

Figure 11-1: A scheme of the role of proteomics in personalized management of cancer................... 340

Additional Details

Publisher

Jain PharmaBiotech

Publisher Information

Jain PharmaBiotech was formed by Prof. Dr. K.K.Jain in 1996 for basic as well as clinical research and to provide consulting services for the biopharmaceutical industries.

Reference

117629 |

Number of Pages

656

Report Format

PDF

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This report is published by Jain PharmaBiotech

Jain PharmaBiotech was formed by Prof. Dr. K.K.Jain in 1996 for basic as well as clinical research and to provide consulting services for the biopharmaceutical industries.

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