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Contract Biomanufacturing Services Global Market - Forecast to 2025 [Report Updated: 17-08-2017]

Published by IQ4I: 17 Aug 2017 | 111599 | In Stock

Introduction

The contract biomanufacturing global market is expected to grow at double digit CAGR to reach .6 billion by 2025.

Biomanufacturing is a widely used term to describe manufacture of biologic molecules for various stages of drug development right from pre-clinical stage to commercial supply. The biologic drug manufacturing is a complex process involving huge capital and sound technical expertise. Many large and small pharmaceutical companies are turning to outsourcing the drug manufacture process to reduce capital investments on capacities and focus more on their core competencies. Contract manufacturing organizations, particularly for R&D and clinical trials, are making product manufacture, more efficient and often less costly. In addition to that, the use of single-use bioreactors is effectively reducing the manufacture facility cost. This option is more viable for smaller and low-funded companies for their in-house candidate product manufacturing needs, whereby, the companies can avoid -0 million facility costs for construction of fixed, dedicated stainless steel bioreactor-based bioprocessing systems and outsource their manufacturing requirements to CMOs which use single-use facilities which typically cost - million for commercial manufacture.

There is a continued growth of biopharmaceutical market which is expected to nearly double in next 10 years. This will be a result of continued new product approvals, expansion of indications for current products which include less-developed countries becoming more affluent and increased drug demand of the aging population in the U.S. and other major pharmaceutical markets. Aging populations are at a high risk of developing chronic diseases such as cancer and arthritis and these diseases are being precisely targeted using biopharmaceuticals. Many blockbuster drugs losing their exclusivity are also giving room for many biosimilar (and bio-betters) companies to enter into the world’s biopharmaceuticals market subsequently attracting many CROs, CDMOs, and CMOs to enter into the picture. Hence, there is every reason to assume that future growth in biopharmaceutical outsourcing will continue at a minimum X% in western countries to about X% in Asian countries.

Now-a-days CMOs are gaining much prominence due to increased demand for the clinical and commercial supply of biologics. Such prominence is achieved mainly through capacity expansions or more easily through mergers and acquisitions. In September 2016, Asahi Glass, a Japanese manufacturer of glass, chemicals, and high-tech materials acquired a leading European bio-CMO, Biomeva Holding GmbH to expand their life science business and expand into newer geographies. Contract manufacturing services are mainly benefitting the small scale companies which lack the facilities for the biomanufacturing and also intend to not invest in fixed assets like steel bioreactors and bioprocessing facilities thus giving opportunity for the CMOs to gain market presence.

The contract biomanufacturing global market is dominated by North America which contributes to revenue of $XX billion in 2016 growing at a CAGR of X% according to IQ4I estimation. The Asia Pacific region is witnessing huge growth opportunities in terms of biologics outsourcing and many local contract manufacturing organizations are taking the lead in making this region the most sought after destination for biologics outsourcing. Some of the reasons why countries such as China and India are favourite destinations for such projects include the lower cost of labour, higher technical expertise and favourable government regulations in countries such as China. The Asia Pacific region is valued at $X billion in 2016 and is expected to grow at a strong X% CAGR from 2016-2025 reaching $X billion by 2025.

The global bio-manufacturing outsourcing market is driven by factors such as globalization of bio-manufacturing facilities, increased funding from private venture capitals and government organizations, increasing outsourcing budgets and emergence of latest technologies such as single-use bioreactors. Increased funding has been seen as a boon for Chinese CMOs for becoming a lucrative market for biomanufacturing outsourcing. An example of such funding includes Autek Bio who raised an impressive 0 million for building Asia’s largest CMO facility in south Beijing from private and government sources. There are restraints and threats as well which could potentially hamper the biomanufacturing outsourcing market. These include unequal distribution of biomanufacturing capacities around the globe which could pose capacity constrains in future, Stringent regulatory affairs and mandatory cGMP certifications which could make the drug manufacture process to further low down, outsourcing being restricted to only small and mid-sized companies are another major restraint where large companies are looking for CMOs as an option only when there are insufficient capabilities internally.

Table of Contents
for Contract Biomanufacturing Services Global Market - Forecast to 2025 [Report Updated: 17-08-2017]

  • 1 CONTRACT BIOMANUFACTURING GLOBAL MARKET 15

    1.1 EXECUTIVE SUMMARY 15

    2 MARKET ANALYSIS 17

    2.1 FACTORS INFLUENCING MARKET 17

    2.1.1 DRIVERS AND OPPORTUNITIES 18

    2.1.1.1 Globalization of outsourcing for biomanufacturing 18

    2.1.1.2 Increased funding from private investors and government for development of CMOs 18

    2.1.1.3 Emergence of single use bioreactors 19

    2.1.1.4 Increasing biologics approvals in the past year 19

    2.1.1.5 Successful collaboration and low cost for outsourcing 20

    2.1.2 RESTRAINTS AND THREATS 21

    2.1.2.1 High requirement for capital investments restraining many CMOs to enter the biologics space 21

    2.1.2.2 Risk of product contamination & maintaining high productivity 22

    2.1.2.3 Entry of large pharmaceutical company with exess capacity into the CMO market 23

    2.1.2.4 Stringent regulations and mandatory requirement of cGMP certifications 23

    3 CONTRACT BIOMANUFACTURING SERVICES 26

    3.1.1 INTRODUCTION 26

    3.2 CONTRACT BIOMANUFACTURING, BY PROCESS 34

    3.2.1 BIOMANUFACTURING BY MAMMALIAN CELL CULTURE 36

    3.2.2 BIOMANUFACTURING BY MICROBIAL CELL CULTURE 39

    3.2.3 BIOMANUFACTURING BY OTHER CELL CULTURE 42

    3.3 CONTRACT BIOMANUFACTURING GLOBAL MARKET, BY END USERS 43

    3.3.1 CONTRACT BIOMANUFACTURING OF DIAGNOSTICS 44

    3.3.2 CONTRACT BIOMANUFACTURING OF RESEARCH REAGENTS 45

    3.3.3 CONTRACT BIOMANUFACTURING OF THERAPEUTICS 46

    3.4 CONTRACT BIOMANUFACTURING GLOBAL MARKET, BY REGION 51

    3.5 COMPETITIVE LANDSCAPE 54

    3.5.1 CAPACITY COMPARISON 54

    3.5.2 CONTRACT BIOMANUFACTURING GLOBAL MARKET SHARE, BY LEADING PLAYERS 57

    3.6 COMPANY DEVELOPMENTS 59

    3.6.1 MERGER AND ACQUISITION BY CMOS 60

    3.6.2 COLLABORATIONS 65

    3.6.3 CAPACITY EXPANSIONS 80

    4 COMPANY PROFILES 87

    4.1 ABZENA PLC 87

    4.1.1 OVERVIEW 87

    4.1.2 FINANCIALS 89

    4.1.3 SERVICE PORTFOLIO 91

    4.1.4 KEY DEVELOPMENTS 91

    4.1.5 SWOT ANALYSIS 93

    4.2 ALBANY MOLECULAR RESEARCH INC 94

    4.2.1 OVERVIEW 94

    4.2.2 FINANCIALS 96

    4.2.3 SERVICE PORTFOLIO 98

    4.2.4 KEY DEVELOPMENTS 99

    4.2.5 SWOT ANALYSIS 100

    4.3 ASAHI GLASS CO. LTD. 101

    4.3.1 OVERVIEW 101

    4.3.2 FINANCIALS 103

    4.3.3 SERVICE PORTFOLIO 104

    4.3.4 KEY DEVELOPMENTS 105

    4.3.5 SWOT ANALYSIS 108

    4.4 BOEHRINGER INGELHEIM 109

    4.4.1 OVERVIEW 109

    4.4.2 FINANCIALS 111

    4.4.3 SERVICE PORTFOLIO 113

    4.4.4 KEY DEVELOPMENTS 114

    4.4.5 SWOT ANALYSIS 115

    4.5 CATALENT INC. 116

    4.5.1 OVERVIEW 116

    4.5.2 FINANCIALS 118

    4.5.3 SERVICE PORTFOLIO 120

    4.5.4 KEY DEVELOPMENTS 121

    4.5.5 SWOT ANALYSIS 124

    4.6 CHARLES RIVER LABORATORIES 125

    4.6.1 OVERVIEW 125

    4.6.2 FINANCIALS 127

    4.6.3 SERVICE PORTFOLIO 129

    4.6.4 KEY DEVELOPMENTS 130

    4.6.5 SWOT ANALYSIS 132

    4.7 FUJIFILM HOLDINGS CORPORATION 133

    4.7.1 OVERVIEW 133

    4.7.2 FINANCIALS 135

    4.7.3 SERVICE PORTFOLIO 138

    4.7.4 KEY DEVELOPMENTS 138

    4.7.5 SWOT ANALYSIS 140

    4.8 HORIZON DISCOVERY GROUP, PLC 141

    4.8.1 OVERVIEW 141

    4.8.2 FINANCIALS 143

    4.8.3 SERVICE PORTFOLIO 145

    4.8.4 KEY DEVELOPMENTS 146

    4.8.5 SWOT ANALYSIS 148

    4.9 INNOVENT BIOLOGICS 149

    4.9.1 OVERVIEW 149

    4.9.2 FINANCIALS 149

    4.9.3 SERVICE PORTFOLIO 149

    4.9.4 KEY DEVELOPMENTS 149

    4.9.5 SWOT ANALYSIS 150

    4.10 JHL BIOTECH INC. 151

    4.10.1 OVERVIEW 151

    4.10.2 FINANCIALS 151

    4.10.3 SERVICE PORTFOLIO 151

    4.10.4 KEY DEVELOPMENTS 152

    4.10.5 SWOT ANALYSIS 154

    4.11 LONZA GROUP 155

    4.11.1 OVERVIEW 155

    4.11.2 FINANCIALS 157

    4.11.3 SERVICE PORTFOLIO 160

    4.11.4 KEY DEVELOPMENTS 160

    4.11.5 SWOT ANALYSIS 162

    4.12 MERCK KGAA 163

    4.12.1 OVERVIEW 163

    4.12.2 FINANCIALS 165

    4.12.3 PRODUCT PORTFOLIO 167

    4.12.4 KEY DEVELOPMENTS 169

    4.12.5 SWOT ANALYSIS 172

    4.13 PATHEON N.V. 173

    4.13.1 OVERVIEW 173

    4.13.2 FINANCIALS 175

    4.13.3 SERVICE PORTFOLIO 176

    4.13.4 KEY DEVELOPMENTS 177

    4.13.5 SWOT ANALYSIS 179

    4.14 PROTEOGENIX 180

    4.14.1 OVERVIEW 180

    4.14.2 FINANCIALS 180

    4.14.3 SERVICE PORTFOLIO 180

    4.14.4 KEY DEVELOPMENTS 181

    4.14.5 SWOT ANALYSIS 182

    4.15 RENTSCHLER BIOTECHNOLOGIE GMBH 183

    4.15.1 OVERVIEW 183

    4.15.2 FINANCIALS 184

    4.15.3 SERVICE PORTFOLIO 184

    4.15.4 KEY DEVELOPMENTS 184

    4.15.5 SWOT ANALYSIS 186

    4.16 SELEXIS SA 187

    4.16.1 OVERVIEW 187

    4.16.2 FINANCIALS 187

    4.16.3 SERVICE PORTFOLIO 187

    4.16.4 KEY DEVELOPMENTS 188

    4.16.5 SWOT ANALYSIS 190

    4.17 SYNGENE INTERNATIONAL 191

    4.17.1 OVERVIEW 191

    4.17.2 FINANCIALS 193

    4.17.3 SERVICE PORTFOLIO 194

    4.17.4 KEY DEVELOPMENTS 197

    4.17.5 SWOT ANALYSIS 198

    4.18 WUXI APPTEC 199

    4.18.1 OVERVIEW 199

    4.18.2 FINANCIALS 200

    4.18.3 SERVICE PORTFOLIO 200

    4.18.4 KEY DEVELOPMENTS 203

    4.18.5 SWOT ANALYSIS 205

List Of Tables
in Contract Biomanufacturing Services Global Market - Forecast to 2025 [Report Updated: 17-08-2017]

LIST OF TABLES


TABLE 1 CAPACITY COMPARISON OF CONTRACT MANUFACTURING ORGANIZATIONS V’S IN-HOUSE CAPACITIES (L) 29

TABLE 2 CONTRACT BIOMANUFACTURING GLOBAL MARKET REVENUE, BY STAGE ($BN) 33

TABLE 3 CONTRACT MANUACTURING ORGANIZATIONS CAPACITY, BY PROCESS (L) 39

TABLE 4 CONTRACT BIOMANUFACTURING GLOBAL MARKET REVENUE, BY PROCESS ($BN) 35

TABLE 5 ANTICANCER DRUGS SYNTHESIZED IN MICROBIAL CELL CULTURE 41

TABLE 6 BIOMANUFACTURING OUTSOURCING GLOBAL MARKET BY END USERS ($BN) 43

TABLE 7 SECOND GENERATION PROTEIN THERAPEUTICS 48

TABLE 8 THERAPEUTIC VACCINES IN PIPELINE 50

TABLE 9 BIOMANUFACTURING OUTSOURCING GLOBAL MARKET BY REGION ($BN) 53

TABLE 10 COMPANY COMPARISON MATRIX, BY MANUFACTURING CAPABILITY 56

TABLE 11 MERGERS AND ACQUITIONS (2015-2017) 61

TABLE 12 COLLABORATIONS (2016-2017) 65

TABLE 13 CAPACITY EXPANSIONS (2016-2017) 80

TABLE 14 ABZENA PLC: TOTAL REVENUE AND R&D EXPENSES (2014-2016) ($MN) 89

TABLE 15 ABZENA PLC: TOTAL REVENUE, BY SEGMENT, (2014-2016) ($MN) 90

TABLE 16 ALBANY MOLECULAR RESEARCH INC: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 96

TABLE 17 ALBANY MOLECULAR RESEARCH INC: TOTAL REVENUE, BY SEGMENTS, (2014-2016) ($MN) 97

TABLE 18 ALBANY MOLECULAR RESEARCH: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 98

TABLE 19 ASAHI GLASS CO. LTD.: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 103

TABLE 20 ASAHI GLASS CO. LTD. : TOTAL REVENUE, BY SEGMENTS, (2014-2016) ($MN) 104

TABLE 21 BOEHRINGER INGELHEIM: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 111

TABLE 22 BOEHRINGER INGELHEIM: TOTAL REVENUE, BY SEGMENTS, (2014-2016) ($MN) 112

TABLE 23 BOEHRINGER INGELHEIM: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 113

TABLE 24 CATALENT INC: TOTAL REVENUE AND R&D EXPENSES (2014-2016) ($MN) 118

TABLE 25 CATALENT INC: TOTAL REVENUE, BY SEGMENT, (2014-2016) ($MN) 119

TABLE 26 CATALENT INC: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 120

TABLE 27 CHARLES RIVER LABORATORIES: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 127

TABLE 28 CHARLES RIVER LABORATORIES: TOTAL REVENUE, BY SEGMENTS, (2014-2016) ($MN) 128

TABLE 29 CHARLES RIVER LABORATORIES: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 129

TABLE 30 FUJIFILM HOLDINGS CORPORATION : TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 135

TABLE 31 FUJIFILM HOLDINGS CORPORATION : TOTAL REVENUE, BY SEGMENTS (2014-2016) ($MN) 136

TABLE 32 FUJIFILM HOLDINGS CORPORATION : TOTAL REVENUE, BY GEOGRAPHY (2014-2016) ($MN) 137

TABLE 33 HORIZON DISCOVERY GROUP: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 143

TABLE 34 HORIZON DISCOVERY GROUP: TOTAL REVENUE, BY SEGMENTS, (2014-2016) ($MN) 144

TABLE 35 HORIZON DISCOVERY GROUP: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 145

TABLE 36 LONZA GROUP: TOTAL REVENUE AND R&D EXPENSES (2014-2016) ($MN) 157

TABLE 37 LONZA GROUP: TOTAL REVENUE, BY SEGMENT, (2014-2016) ($MN) 158

TABLE 38 LONZA GROUP: TOTAL REVENUE, BY GEOGRAPHY (2014-2016) ($MN) 159

TABLE 39 MERCK KGAA: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 165

TABLE 40 MERCK KGAA: TOTAL REVENUE, BY SEGMENTS, (2014-2016) ($MN) 166

TABLE 41 MERCK KGAA: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 167

TABLE 42 PATHEON N.V.: TOTAL REVENUE AND R&D EXPENSES (2014-2016) ($MN) 175

TABLE 43 PATHEON N.V.: TOTAL REVENUE, BY SEGMENT, (2014-2016) ($MN) 176

TABLE 44 SYNGENE INTERNATIONAL: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 193

TABLE 45 SYNGENE INTERNATIONAL: TOTAL REVENUE, BY GEOGRAPHY, (2014-2016) ($MN) 194

TABLE 46 WUXI APPTEC: TOTAL REVENUE AND R&D EXPENSES, (2014-2016) ($MN) 200

List Of Figures, Charts and Diagrams
in Contract Biomanufacturing Services Global Market - Forecast to 2025 [Report Updated: 17-08-2017]

LIST OF FIGURES



FIGURE 1 MARKET DYNAMICS 17

FIGURE 2 INDUSTRY PIPELINE FOR SMALL MOLECULE V’S BIOLOGICS 28

FIGURE 3 GLOBAL MANUFACTURING CAPACITY, CGMP V’S NON-CGMP, INHOUSE V’S CMO, 2016 30

FIGURE 4 CAPACITY UTILIZATION OF CONTRACT MANUFACTURING ORGANIZATIONS, BY STAGE (L) 32

FIGURE 5 CONTRACT BIOMANUFACTURING GLOBAL MARKET REVENUE, BY STAGE ($BN) 34

FIGURE 6 CAPACITY COMPARISON OF MAMMALIAN, MICROBIAL AND OTHER CULTURE SYSTEMS (L) 38

FIGURE 7 CONTRACT BIOMANUFACTURING GLOBAL MARKET REVENUE, BY PROCESS ($BN) 36

FIGURE 8 BIO-MANUFACTURING OUTSOURCING GLOBAL MARKET, BY END USERS ($BN) 44

FIGURE 9 OUTLOOK OF BIOLOGICS CMO GLOBAL MARKET, BY REGION ($BN) AND PRODUCTION IN METRIC TONS, 2016 52

FIGURE 10 CAPACITY COMPOSITION OF TOP 10 CONTRACT MANUFACTURING ORGANIZATIONS (L) 55

FIGURE 11 MARKET SHARE ANALYSIS BY CONTRACT BIOMANUFACTURING MAJOR PLAYERS, 2016 59

FIGURE 12 COMPANY DEVELOPMENTS (2016-2017) 60

FIGURE 13 OVERVIEW: ABZENA PLC 88

FIGURE 14 SWOT: ABZENA PLC 93

FIGURE 15 OVERVIEW: ALBANY MOLECULAR RESEARCH INSTITUTE 95

FIGURE 16 SWOT: ALBANY MOLECULAR RESEARCH, INC 100

FIGURE 17 OVERVIEW: ASAHI GLASS CO. LTD. 102

FIGURE 18 SWOT: ASAHI GLASS CO. LTD. 108

FIGURE 19 OVERVIEW: BOEHRINGER INGELHEIM 110

FIGURE 20 SWOT: BOEHRINGER INGELHEIM 115

FIGURE 21 OVERVIEW: CATALENT INC. 117

FIGURE 22 SWOT: CATALENT INC. 124

FIGURE 23 OVERVIEW: CHARLES RIVER LABORATORIES 126

FIGURE 24 SWOT: CHARLES RIVER LABORATORIES 132

FIGURE 25 OVERVIEW: FUJIFILM HOLDINGS CORPORATION 134

FIGURE 26 SWOT: FUJIFILM DIOSYNTH BIOTECHNOLOGIES 140

FIGURE 27 OVERVIEW: HORIZON DISCOVERY GROUP, PLC 142

FIGURE 28 SWOT: HORIZON DISCOVERY GROUP, PLC 148

FIGURE 29 SWOT: INNOVENT BIOLOGICS 150

FIGURE 30 SWOT: JHL BIOTECH INC. 154

FIGURE 31 OVERVIEW: LONZA GROUP 156

FIGURE 32 SWOT: LONZA GROUP 162

FIGURE 33 OVERVIEW: MERCK KGAA 164

FIGURE 34 SWOT: MERCK KGAA 172

FIGURE 35 OVERVIEW: PATHEON N.V. 174

FIGURE 36 SWOT: PATHEON N.V. 179

FIGURE 37 SWOT: PROTEOGENIX 182

FIGURE 38 SWOT: RENTSCHLER BIOTECHNOLOGIE 186

FIGURE 39 SWOT: SELEXIS SA 190

FIGURE 40 OVERVIEW: SYNGENE INTERNATIONAL 192

FIGURE 41 SWOT: SYNGENE INTERNATIONAL 198

FIGURE 42 SWOT: WUXI APPTEC 205

Additional Details

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IQ4I

Publisher Information

IQ4I is a global strategy, consulting and a leading market research company. Our clients include leading businesses, investment banks, researchers and government agencies.



We are a team of highly qualified market researchers and consultants, committed to help clients make strategic decisions by providing relevant and firmly reliable data support. We enable our clients to identify the market opportunities with best-in-class market intelligence reports and Business Development & licensing services and provide support in hiring with best talents.

Reference

111599 | Contract Biomanufacturing Services Global Market Report - 17082017

Number of Pages

206

Report Format

PDF

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IQ4I is a global strategy, consulting and a leading market research company. Our clients include leading businesses, investment banks, researchers and government agencies.

We are a team of highly qualified market researchers and consultants, committed to help clients make strategic decisions by providing relevant and firmly reliable data support. We enable our clients to identify the market opportunities with best-in-class market intelligence reports and Business Development & licensing services and provide support in hiring with best talents.

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