Corneal Neovascularization - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Corneal Neovascularization - Pipeline Review, H1 2020, provides an overview of the Corneal Neovascularization (Ophthalmology) pipeline landscape.Corneal neovascularization is a corneal condition where oxygen deprivation and stress cause abnormal blood vessels to grow in the normally clear, translucent cornea. Predisposing factors include infections, trau

Keratitis - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Keratitis - Pipeline Review, H1 2020, provides an overview of the Keratitis (Ophthalmology) pipeline landscape.Keratitis is an inflammation of the cornea. Symptoms include eye redness, eye pain, blurred vision, decreased vision and sensitivity to light. Risk factors include virus infections, injury, climatic condition and reduced immunity. Report HighlightsGlobal Markets

Optic Neuritis - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Optic Neuritis - Pipeline Review, H1 2020, provides an overview of the Optic Neuritis (Ophthalmology) pipeline landscape.Optic neuritis is an inflammation of the optic nerve, the bundle of nerve fibers that transmits visual information from eye to brain. Symptoms include pain, vision loss, dyschromatopsia, Uhthoff’s phenomenon and flashing lights. Risk factors inc

Bronchiectasis - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Bronchiectasis - Pipeline Review, H1 2020, provides an overview of the Bronchiectasis (Respiratory) pipeline landscape.Bronchiectasis is a chronic condition where the walls of the bronchial tubes are permanently damaged. These damage allow bacteria and mucus to build up in lungs. Bronchiectasis is divided into two categories cystic fibrosis (CF) bronchiectasis and n

Chronic Obstructive Pulmonary Disease (COPD) - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Chronic Obstructive Pulmonary Disease - Pipeline Review, H1 2020, provides an overview of the Chronic Obstructive Pulmonary Disease (Respiratory) pipeline landscape.Chronic obstructive pulmonary disease (COPD) is a group of lung diseases. It is characterized by inability to completely breathe out air from the lungs leading to shortness

Idiopathic Pulmonary Fibrosis - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Idiopathic Pulmonary Fibrosis - Pipeline Review, H1 2020, provides an overview of the Idiopathic Pulmonary Fibrosis (Respiratory) pipeline landscape.Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by inflammation and scarring of lung tissue and loss of lung function. Symptoms of IPF include dry cough, shortness of

Asthma - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Asthma - Pipeline Review, H1 2020, provides an overview of the Asthma (Respiratory) pipeline landscape.Asthma is a chronic disease involving the airways in the lungs. These airways, or bronchial tubes, allow air to come in and out of the lungs. Symptoms include shortness of breath, chest tightness or pain, chronic coughing and trouble sleeping due to coughing or wheezing. T

Organophosphate and Carbamate Poisoning - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Organophosphate and Carbamate Poisoning - Pipeline Review, H1 2020, provides an overview of the Organophosphate and Carbamate Poisoning (Other Diseases) pipeline landscape.Organophosphates and carbamates are common insecticides that inhibit cholinesterase activity, causing acute muscarinic manifestations (salivation, lacrimation, urination,

Atherosclerosis - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Atherosclerosis - Pipeline Review, H1 2020, provides an overview of the Atherosclerosis (Cardiovascular) pipeline landscape.Atherosclerosis (or arteriosclerotic vascular disease) is a condition where the arteries become narrowed and hardened due to an excessive build up of plaque around the artery wall. The disease disrupts the flow of blood around the body, posing

Hypertrophic Cardiomyopathy - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Hypertrophic Cardiomyopathy - Pipeline Review, H1 2020, provides an overview of the Hypertrophic Cardiomyopathy (Cardiovascular) pipeline landscape.Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle (myocardium) becomes abnormally thick (hypertrophied). The thickened heart muscles make it harder for the heart to pump blood. Symptom

Stroke - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Stroke - Pipeline Review, H1 2020, provides an overview of the Stroke (Cardiovascular) pipeline landscape.Stroke is a condition in which the brain cells suddenly die because of a lack of oxygen. Symptoms occur rapidly and usually last a short time, from a few minutes to a couple of hours. The symptoms of a stroke usually appear suddenly. Initially the person may feel sick,

Critical Limb Ischemia - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Critical Limb Ischemia - Pipeline Review, H1 2020, provides an overview of the Critical Limb Ischemia (Cardiovascular) pipeline landscape.Critical limb ischemia (CLI) is the most severe form of peripheral arterial disease (PAD). It is caused by chronic inflammatory processes associated with atherosclerosis that result in reduced blood flow to the legs, feet

Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD) - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Peripheral Arterial Disease Peripheral Vascular Disease - Pipeline Review, H1 2020, provides an overview of the Peripheral Arterial Disease Peripheral Vascular Disease (Cardiovascular) pipeline landscape.Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside

Behcet Disease - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Behcet Disease - Pipeline Review, H1 2020, provides an overview of the Behcet Disease (Cardiovascular) pipeline landscape."Behcet disease (BEH-chets), sometimes called Behcet syndrome, Morbus Behçet, or Silk Road disease, is a rare immune-mediated systemic vasculitis. The more common symptoms include sores in the mouth and on the genitals(sex organs). More serious

Ventricular Tachycardia - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Ventricular Tachycardia - Pipeline Review, H1 2020, provides an overview of the Ventricular Tachycardia (Cardiovascular) pipeline landscape.Ventricular tachycardia is a very fast heart rhythm that begins in the ventricles. Symptoms of ventricular tachycardia include dizziness, fainting, fatigue, chest pain and shortness of breath. Causes include cardiomyopa

Vaso-Occlusive Crisis Associated With Sickle Cell Disease - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Vaso-Occlusive Crisis Associated With Sickle Cell Disease - Pipeline Review, H1 2020, provides an overview of the Vaso-Occlusive Crisis Associated With Sickle Cell Disease (Cardiovascular) pipeline landscape.Vaso-occlusive crisis associated with sickle cell disease is a painful episode that occurs in people who have sickle

Parkinson's Disease - Pipeline Review, H1 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Parkinson's Disease - Pipeline Review, H1 2020, provides an overview of the Parkinson's Disease (Central Nervous System) pipeline landscape.Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement dysfunctions. The main finding in brains of people with PD is loss of dopaminergic neurons in substantia nigra. Symptoms generally develop s

Free Fatty Acid Receptor 1 - Pipeline Review, H1 2020SummaryFree Fatty Acid Receptor 1 (G Protein Coupled Receptor 40 or GPR40 or FFAR1) pipeline Target constitutes close to 16 molecules. Out of which approximately 12 molecules are developed by companies and remaining by the universities/institutes. The latest report Free Fatty Acid Receptor 1 - Pipeline Review, H1 2020, outlays comprehensive information on the Free Fatty Acid Receptor 1 (G Protein Coupled Receptor 40 or GPR40 or FFAR1) targeted

Lysophosphatidic Acid Receptor 1 - Pipeline Review, H1 2020SummaryLysophosphatidic Acid Receptor 1 (Lysophosphatidic Acid Receptor Edg 2 or LPAR1) - Lysophosphatidic acid receptor 1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA). Lysophosphatidic acid (LPA) receptor belongs to a group known as EDG receptors. EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, and smooth muscle contraction, inhibitio

Adenosine Receptor A3 - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Adenosine Receptor A3 - Pipeline Review, H1 2020'; Adenosine Receptor A3 (ADORA3) pipeline Target constitutes close to 16 molecules. Out of which approximately 15 molecules are developed by companies and remaining by the universities/institutes. Adenosine Receptor A3 (ADORA3) - The adenosine A3 receptor, also known as ADORA3, is an adenosine receptor. Adenosine A3 receptors are G protein-coupled re

Type 2 Angiotensin II Receptor - Pipeline Review, H1 2020SummaryType 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) pipeline Target constitutes close to 10 molecules. Out of which approximately 8 molecules are developed by companies and remaining by the universities/institutes. The latest report Type 2 Angiotensin II Receptor - Pipeline Review, H1 2020, outlays comprehensive information on the Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted

Growth Hormone Secretagogue Receptor Type 1 - Pipeline Review, H1 2020SummaryGrowth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Growth hormone secretagogue receptor (GHSR) also known as ghrelin receptor, is a G protein-coupled receptor that binds ghrelin. Ghrelin is an appetite-regulating factor secreted from peripheral organs via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. The pathway activat

Orexin Receptor Type 1 - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Orexin Receptor Type 1 - Pipeline Review, H1 2020'; Orexin Receptor Type 1 (Hypocretin Receptor Type 1 or HCRTR1) pipeline Target constitutes close to 14 molecules. Orexin Receptor Type 1 (Hypocretin Receptor Type 1 or HCRTR1) - Orexin receptor type 1 (Ox1R or OX1) is a protein that is encoded by the HCRTR1 gene. The orexin 1 receptor (OX1) is a G-protein coupled receptor that is highly expressed

Orexin Receptor Type 2 - Pipeline Review, H1 2020SummaryOrexin Receptor Type 2 (Hypocretin Receptor Type 2 or HCRTR2) pipeline Target constitutes close to 9 molecules. Out of which approximately 8 molecules are developed by companies and remaining by the universities/institutes. The latest report Orexin Receptor Type 2 - Pipeline Review, H1 2020, outlays comprehensive information on the Orexin Receptor Type 2 (Hypocretin Receptor Type 2 or HCRTR2) targeted therapeutics, complete with analysis by

Melanocortin Receptor 4 - Pipeline Review, H1 2020SummaryMelanocortin Receptor 4 (MC4R) - Melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in the hypothalamic leptin-melanocortin signaling pathway. MC4R is encoded by the MC4R gene. Activation of the MC4R plays a key role in the maintenance of energy homeostasis and is associated with suppression of food intake. Melanocortin Receptor 4 (MC4R) pipeline Target constitutes close to 10 molecules. Out of which approximately 8 mo

Melanocyte Stimulating Hormone Receptor - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Melanocyte Stimulating Hormone Receptor - Pipeline Review, H1 2020'; Melanocyte Stimulating Hormone Receptor (Melanocortin Receptor 1 or MSHR or MC1R) pipeline Target constitutes close to 12 molecules. Melanocyte Stimulating Hormone Receptor (Melanocortin Receptor 1 or MSHR or MC1R) - Melanocyte-stimulating hormone receptor (MSHR) also known as melanocortin 1 receptor (MC1R), is a

Nociceptin Receptor - Pipeline Review, H1 2020SummaryNociceptin Receptor (Kappa Type 3 Opioid Receptor or KOR3 or Orphanin FQ Receptor or OPRL1) pipeline Target constitutes close to 16 molecules. Out of which approximately 14 molecules are developed by companies and remaining by the universities/institutes. The latest report Nociceptin Receptor - Pipeline Review, H1 2020, outlays comprehensive information on the Nociceptin Receptor (Kappa Type 3 Opioid Receptor or KOR3 or Orphanin FQ Receptor or

Gastric Inhibitory Polypeptide Receptor - Pipeline Review, H1 2020SummaryGastric Inhibitory Polypeptide Receptor (Glucose Dependent Insulinotropic Polypeptide Receptor or GIPR) - Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein in humans which is encoded by the GIPR gene. GIPR is expressed on pancreatic beta-cells which lead to activation and release of insulin. The transcription of this protein is positively controlled by glucose molecules. GIPR is express

Human cytomegalovirus 65 kDa Phosphoprotein - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Human cytomegalovirus 65 kDa Phosphoprotein - Pipeline Review, H1 2020'; Human cytomegalovirus 65 kDa Phosphoprotein (PP65 or 65 kDa Matrix Phosphoprotein or Tegument Protein UL83 or UL83) pipeline Target constitutes close to 9 molecules. Out of which approximately 8 molecules are developed by companies and remaining by the universities/institutes. Human cytomegalovirus 65 kDa

Hepatocyte Growth Factor - Pipeline Review, H1 2020SummaryHepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) pipeline Target constitutes close to 15 molecules. The latest report Hepatocyte Growth Factor - Pipeline Review, H1 2020, outlays comprehensive information on the Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) an

Glial Cell Line Derived Neurotrophic Factor - Pipeline Review, H1 2020SummaryGlial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) - Glial -derived neurotrophic factor is a member of the cysteine-knot superfamily of growth factors. It promotes the survival and differentiation of dopaminergic neurons and was able to prevent apoptosis of motor neurons. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncoge

Growth/Differentiation Factor 8 - Pipeline Review, H1 2020SummaryAccording to the recently published report 'GrowthDifferentiation Factor 8 - Pipeline Review, H1 2020'; Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) pipeline Target constitutes close to 9 molecules. Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Myostatin also known as growth differentiation factor 8 or GDF-8 is a myokine a protein produced and released by myocytes. This protein is part of the transfor

Placenta Growth Factor - Pipeline Review, H1 2020SummaryPlacenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF) pipeline Target constitutes close to 21 molecules. The latest report Placenta Growth Factor - Pipeline Review, H1 2020, outlays comprehensive information on the Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route

Histone Deacetylase 1 - Pipeline Review, H1 2020SummaryHistone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Histone deacetylase 1 is an enzyme encoded by the HDAC1 gene. The protein encoded by this gene belongs to the histone deacetylase family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2,

Histone Deacetylase 2 - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Histone Deacetylase 2 - Pipeline Review, H1 2020'; Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1 Associated Factor 1 or HDAC2 or EC 3.5.1.98) pipeline Target constitutes close to 31 molecules. Out of which approximately 27 molecules are developed by companies and remaining by the universities/institutes. Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1 Ass

Gamma-Aminobutyric Acid Receptor Subunit Gamma 2 - Pipeline Review, H1 2020SummaryGamma-Aminobutyric Acid Receptor Subunit Gamma 2 (GABA(A) Receptor Subunit Gamma 2 or GABRG2) pipeline Target constitutes close to 5 molecules. Out of which approximately 4 molecules are developed by companies and remaining by the universities/institutes. The latest report Gamma-Aminobutyric Acid Receptor Subunit Gamma 2 - Pipeline Review, H1 2020, outlays comprehensive information on the Gamma-Aminobutyric Acid Re

Retinoic Acid Receptor Alpha - Pipeline Review, H1 2020SummaryRetinoic Acid Receptor Alpha (RAR Alpha or Nuclear Receptor Subfamily 1 Group B Member 1 or NR1B1 or RARA) - Retinoic acid receptor alpha (RARA) is a nuclear receptor that is encoded by the RARA gene. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. It promotes the survival and development of early meiotic prophase spermatocytes. It regulates expression of target gen

Retinoic Acid Receptor Gamma - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Retinoic Acid Receptor Gamma - Pipeline Review, H1 2020'; Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) pipeline Target constitutes close to 17 molecules. Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Retinoic acid receptor gamma (RARG) is a nuclear receptor that is enc

Estrogen Receptor Beta - Pipeline Review, H1 2020SummaryEstrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) pipeline Target constitutes close to 20 molecules. Out of which approximately 14 molecules are developed by companies and remaining by the universities/institutes. The latest report Estrogen Receptor Beta - Pipeline Review, H1 2020, outlays comprehensive information on the Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A

Histone Deacetylase 3 - Pipeline Review, H1 2020SummaryHistone Deacetylase 3 (SMAP45 or RPD3 2 or HDAC3 or EC 3.5.1.98) - Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. It participates in the regulation of transcription through its binding w

Gamma Secretase - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Gamma Secretase (EC 3.4.23.) - Pipeline Review, H1 2020'; Gamma Secretase (EC 3.4.23.) pipeline Target constitutes close to 20 molecules. Out of which approximately 17 molecules are developed by companies and remaining by the universities/institutes. Gamma Secretase (EC 3.4.23.) - Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembr

Cathepsin B - Pipeline Review, H1 2020SummaryCathepsin B (APP Secretase or Cathepsin B1 or CTSB or EC 3.4.22.1) pipeline Target constitutes close to 7 molecules. Out of which approximately 5 molecules are developed by companies and remaining by the universities/institutes. The latest report Cathepsin B - Pipeline Review, H1 2020, outlays comprehensive information on the Cathepsin B (APP Secretase or Cathepsin B1 or CTSB or EC 3.4.22.1) targeted therapeutics, complete with analysis by indications

Cathepsin L1 - Pipeline Review, H1 2020SummaryCathepsin L1 (Cathepsin L or Major Excreted Protein or CTSL or EC 3.4.22.15) - Cathepsin L, a lysosomal endopeptidase is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Although commonly recognized as a lysosomal protease, cathepsin L is also secreted. The

Cathepsin S - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Cathepsin S - Pipeline Review, H1 2020'; Cathepsin S (CTSS or EC 3.4.22.27) pipeline Target constitutes close to 7 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes. Cathepsin S (CTSS or EC 3.4.22.27) - Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Cathepsin S has a role in itch and pain, or n

Collagenase 3 - Pipeline Review, H1 2020SummaryCollagenase 3 (Matrix Metalloproteinase 13 or MMP13 or EC 3.4.24.) pipeline Target constitutes close to 5 molecules. Out of which approximately 4 molecules are developed by companies and remaining by the universities/institutes. The latest report Collagenase 3 - Pipeline Review, H1 2020, outlays comprehensive information on the Collagenase 3 (Matrix Metalloproteinase 13 or MMP13 or EC 3.4.24.) targeted therapeutics, complete with analysis by indicat

Matrix Metalloproteinase 9 - Pipeline Review, H1 2020SummaryMatrix Metalloproteinase 9 (Gelatinase B or 92 kDa Type IV Collagenase or 92 kDa Gelatinase or MMP9 or EC 3.4.24.35) - Matrix metallopeptidase 9 (MMP-9) is a matrixin that belong to the zinc-metalloproteinases family. It plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration and bone osteoclastic resorption. MMP9 along with elastase, appears to be a regulatory factor in neutrophil migration a

Coagulation Factor XI - Pipeline Review, H1 2020SummaryAccording to the recently published report 'Coagulation Factor XI - Pipeline Review, H1 2020'; Coagulation Factor XI (Plasma Thromboplastin Antecedent or F11 or EC 3.4.21.27) pipeline Target constitutes close to 22 molecules. Out of which approximately 21 molecules are developed by companies and remaining by the universities/institutes. Coagulation Factor XI (Plasma Thromboplastin Antecedent or F11 or EC 3.4.21.27) - Factor XI or plasma thro

Superoxide Dismutase [Cu-Zn] - Pipeline Review, H1 2020SummarySuperoxide Dismutase [Cu-Zn] (Superoxide Dismutase 1 or Epididymis Secretory Protein Li 44 or SOD1 or EC 1.15.1.1) pipeline Target constitutes close to 16 molecules. Out of which approximately 12 molecules are developed by companies and remaining by the universities/institutes. The latest report Superoxide Dismutase - Pipeline Review, H1 2020, outlays comprehensive information on the Superoxide Dismutase [Cu-Zn] (Superoxide Dismutase