Type 1 Diabetes (Juvenile Diabetes) - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Type 1 Diabetes - Pipeline Review, H2 2020, provides an overview of the Type 1 Diabetes (Metabolic Disorders) pipeline landscape.Type 1 diabetes (T1D) is an autoimmune disease in which a pancreas stops producing insulin, a hormone that enables people to get energy from food. It occurs when the body’s immune system attacks and destroys the insu

Type 2 Diabetes - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Type 2 Diabetes - Pipeline Review, H2 2020, provides an overview of the Type 2 Diabetes (Metabolic Disorders) pipeline landscape.Type 2 diabetes is a chronic condition and is the most common form of diabetes. High levels of glucose are a characteristic feature. The body might become resistant to insulin or may not produce enough amounts. Due to abnormal insulin fun

Hypercholesterolemia - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Hypercholesterolemia - Pipeline Review, H2 2020, provides an overview of the Hypercholesterolemia (Metabolic Disorders) pipeline landscape.Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. This leads in formation of sticky deposits (called plaque) along the artery walls. Plaque can completely block blood flow th

Heterozygous familial hypercholesterolemia (heFH) - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Heterozygous familial hypercholesterolemia - Pipeline Review, H2 2020, provides an overview of the Heterozygous familial hypercholesterolemia (Metabolic Disorders) pipeline landscape.Heterozygous familial hypercholesterolemia (HeFH) is a genetic disorder caused due to a mutation (alteration) of FH from one (affected) parent. Sympto

Obesity - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Obesity - Pipeline Review, H2 2020, provides an overview of the Obesity (Metabolic Disorders) pipeline landscape.Obesity is defined as having an excessive amount of body fat. Obesity increases risk of diseases and health problems such as heart disease, diabetes and high blood pressure. The predisposing factors include age, family history, quitting smoking, lack of sleep an

Gingivitis - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Gingivitis - Pipeline Review, H2 2020, provides an overview of the Gingivitis (Mouth And Dental Disorders) pipeline landscape.Gingivitis is an inflammation of the gums, usually caused by a bacterial infection. Symptoms include sensitive teeth, pus between teeth and gums, loose teeth, gums that are red, tender, or swollen. Risk factors include diabetes, smoking or chewin

Ankylosing Spondylitis (Bekhterev's Disease) - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Ankylosing Spondylitis - Pipeline Review, H2 2020, provides an overview of the Ankylosing Spondylitis (Musculoskeletal Disorders) pipeline landscape.Ankylosing spondylitis is a type of arthritis that affects the spine. Ankylosing spondylitis symptoms include pain and stiffness from the neck down to the lower back. The spine's bones (ver

Axial Spondyloarthritis - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Axial Spondyloarthritis - Pipeline Review, H2 2020, provides an overview of the Axial Spondyloarthritis (Musculoskeletal Disorders) pipeline landscape.Axial spondylitis is a type of inflammatory arthritis involving the spine and/or sacroiliac joints. Axial spondylitis is strongly related to the presence of the HLA-B27 gene. A genetic test for HLA-B27 is ava

Psoriatic Arthritis - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Psoriatic Arthritis - Pipeline Review, H2 2020, provides an overview of the Psoriatic Arthritis (Musculoskeletal Disorders) pipeline landscape.Psoriatic arthritis is a form of arthritis that affects some people who have psoriasis. Symptoms include swollen fingers and toes, foot pain and lower back pain. Risk factors include age, family history and psoriasis. Tr

Muscular Dystrophy - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Muscular Dystrophy - Pipeline Review, H2 2020, provides an overview of the Muscular Dystrophy (Musculoskeletal Disorders) pipeline landscape.Muscular dystrophy is a group of diseases in which muscle fibers are unusually susceptible to damage. These damaged muscles become progressively weaker. Symptoms usually appear before age 6 and may appear as early as infanc

Gouty Arthritis (Gout) - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Gouty Arthritis - Pipeline Review, H2 2020, provides an overview of the Gouty Arthritis (Musculoskeletal Disorders) pipeline landscape.Gout is a type of arthritis where swelling and severe pain develops in joints, especially at the base of the big toe. Gout occurs when uric acid builds up in blood and causes inflammation in the joints. Symptoms include sudde

Osteonecrosis - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Osteonecrosis - Pipeline Review, H2 2020, provides an overview of the Osteonecrosis (Musculoskeletal Disorders) pipeline landscape.Osteonecrosis is bone death caused by poor blood supply to the area. It is most common in the hip and shoulder, but can affect other large joints such as knee, elbow, wrist and ankle. Osteonecrosis can be caused by disease, or a severe tr

Pigmented Villonodular Synovitis - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Pigmented Villonodular Synovitis - Pipeline Review, H2 2020, provides an overview of the Pigmented Villonodular Synovitis (Musculoskeletal Disorders) pipeline landscape.Pigmented villonodular synovitis (PVNS) is a condition that causes the synovium. PVNS is characterized by inflammation and overgrowth of the joint lining. This affects the hip or kn

Dermatomyositis - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Dermatomyositis - Pipeline Review, H2 2020, provides an overview of the Dermatomyositis (Musculoskeletal Disorders) pipeline landscape.Dermatomyositis is a rare inflammatory disease which is characterized by chronic muscle inflammation accompanied by muscle weakness. Symptoms of dermatomyositis include a distinctive skin rash, muscle weakness, and inflammatory myop

Acute Lymphocytic Leukemia - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia - Pipeline Review, H2 2020, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape.Acute lymphocytic leukemia (ALL) is the cancer of the white blood cells due to the production of a large number of immature lymphocytes thus blocking the production of normal blood cells. It enters the blood stream a

Chronic Lymphocytic Leukemia (CLL) - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Chronic Lymphocytic Leukemia - Pipeline Review, H2 2020, provides an overview of the Chronic Lymphocytic Leukemia (Oncology) pipeline landscape.Chronic lymphocytic leukemia (CLL) is a type of cancer that starts from white blood cells (called lymphocytes) in the bone marrow. It then invades the blood. Symptoms usually develop slowly. Symptoms of C

Chronic Myelocytic Leukemia - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Chronic Myelocytic Leukemia - Pipeline Review, H2 2020, provides an overview of the Chronic Myelocytic Leukemia (Oncology) pipeline landscape.Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood. Risk factors for CML include high-do

Non-Hodgkin Lymphoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Non-Hodgkin Lymphoma - Pipeline Review, H2 2020, provides an overview of the Non-Hodgkin Lymphoma (Oncology) pipeline landscape.Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma, NHL, or sometimes just lymphoma) is a cancer that starts in cells called lymphocytes, which are part of the body’s immune system. Symptoms depend on what area of the body

Chondrosarcoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Chondrosarcoma - Pipeline Review, H2 2020, provides an overview of the Chondrosarcoma (Oncology) pipeline landscape.Chondrosarcoma is a malignant cancer whose tumor cells produce a pure hyaline cartilage that results in abnormal bone and/or cartilage growth. Signs and symptoms include pain in the affected area that may worsen at night or during physical activity, sw

Ewing Sarcoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Ewing Sarcoma - Pipeline Review, H2 2020, provides an overview of the Ewing Sarcoma (Oncology) pipeline landscape.Ewing's sarcoma is a primary bone cancer that affects mainly children and adolescents. Ewing's sarcoma can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. There are few symptoms. Th

Anaplastic Astrocytoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Anaplastic Astrocytoma - Pipeline Review, H2 2020, provides an overview of the Anaplastic Astrocytoma (Oncology) pipeline landscape.Anaplastic astrocytoma is a grade III tumor. It accounts for two percent of all brain tumors. It is a type of glioma that develops from star-shaped glial cells (astrocytes), which support nerve cells. Anaplastic astrocytoma grow

Anaplastic Oligoastrocytoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Anaplastic Oligoastrocytoma - Pipeline Review, H2 2020, provides an overview of the Anaplastic Oligoastrocytoma (Oncology) pipeline landscape.Anaplastic oligoastrocytoma is a brain tumor that forms when two types of cells in the brain, called oligodendrocytes and astrocytes, rapidly increase in number to form a mass. These brain cells are known as glial

Gliosarcoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Gliosarcoma - Pipeline Review, H2 2020, provides an overview of the Gliosarcoma (Oncology) pipeline landscape.Gliosarcoma is a type of brain tumor that originates from glial cells. The tumor grows rapidly and symptom will vary depending on the exact location and size of the tumor. Most likely they may be headache, vomiting, cognitive problems, and drowsiness. Treatment

Pontine Glioma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Pontine Glioma - Pipeline Review, H2 2020, provides an overview of the Pontine Glioma (Oncology) pipeline landscape.Pontine gliomas are highly aggressive and difficult to treat brain tumors found at the base of the brain. One of the most common types is diffuse intrinsic pontine glioma (DIPG). DIPG affects the pons portion of the brainstem, rendering nervous system

Neuroblastoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Neuroblastoma - Pipeline Review, H2 2020, provides an overview of the Neuroblastoma (Oncology) pipeline landscape.Neuroblastoma is the cancer of the nerve tissues and neural crest cells of adrenal glands, neck, chest or spinal cord, occurring predominantly in children. It usually begins in the adrenal glands further spreading to other parts of the body. The predispos

Gallbladder Cancer - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Gallbladder Cancer - Pipeline Review, H2 2020, provides an overview of the Gallbladder Cancer (Oncology) pipeline landscape.Gallbladder cancer is a cancer that starts in the gallbladder. Symptoms include abdominal pain, nausea and/or vomiting, jaundice, loss of appetite, fever, itchy skin, dark urine and weight loss. Risk factors include overweight, age, family

Cervical Cancer - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Cervical Cancer - Pipeline Review, H2 2020, provides an overview of the Cervical Cancer (Oncology) pipeline landscape.Cervical cancer occurs when abnormal cells on the cervix grow out of control. Most cervical cancer is caused by a virus called human papillomavirus, or HPV. Abnormal cervical cell changes rarely cause symptoms. Symptoms of cervical cancer may includ

Endometrial Cancer - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Endometrial Cancer - Pipeline Review, H2 2020, provides an overview of the Endometrial Cancer (Oncology) pipeline landscape.Endometrial cancer is cancer that starts in the endometrium, the lining of the uterus (womb). Endometrial cancer is the most common type of uterine cancer. Although the exact cause of endometrial cancer is unknown, increased levels of estro

Vaginal Cancer - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Vaginal Cancer - Pipeline Review, H2 2020, provides an overview of the Vaginal Cancer (Oncology) pipeline landscape.Vaginal cancer is a rare cancer that occurs in vagina. Symptoms includes watery vaginal discharge, a lump or mass in vagina, painful urination, constipation and pelvic pain, vaginal bleeding. Risk factors include age, Smoking, HIV infection and vaginal

Prostate Cancer - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Prostate Cancer - Pipeline Review, H2 2020, provides an overview of the Prostate Cancer (Oncology) pipeline landscape.Prostate cancer is a form of cancer that affects men and starts off in the prostate gland. Prostate cancer usually occurs in older men. Symptoms include trouble urinating, decreased force in the stream of urine, blood in the urine, pain in the lower

Melanoma - Pipeline Review, H2 2020SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Melanoma - Pipeline Review, H2 2020, provides an overview of the Melanoma (Oncology) pipeline landscape.Melanoma is a tumor that develops as a result of the malignant transformation of melanocytes. These cells are derived from the neural crest. Melanomas usually occur on the skin but can arise in other locations where neural crest cells migrate, such as in the gastrointes

Glucokinase - Pipeline Review, H2 2020SummaryGlucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) pipeline Target constitutes close to 14 molecules. Out of which approximately 12 molecules are developed by companies and remaining by the universities/institutes. The latest report Glucokinase - Pipeline Review, H2 2020, outlays comprehensive information on the Glucokinase (Hexokinase D or Hexokinase 4 or GCK or EC 2.7.1.2) targeted therapeutics, complete with analysis by indications, st

Protein Kinase C Epsilon Type - Pipeline Review, H2 2020SummaryProtein Kinase C Epsilon Type (nPKC Epsilon or PRKCE or EC 2.7.11.13) - Protein kinase C (PKC) is an enzyme belonging to a family of serine- and threonine-specific protein kinases that is activated by calcium and the second messenger diacylglycerol. This kinase showed involvement in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin

Transthyretin - Pipeline Review, H2 2020SummaryAccording to the recently published report 'Transthyretin - Pipeline Review, H2 2020'; Transthyretin (ATTR or Prealbumin or TBPA or TTR) pipeline Target constitutes close to 16 molecules. Out of which approximately 14 molecules are developed by companies and remaining by the universities/institutes. Transthyretin (ATTR or Prealbumin or TBPA or TTR) - Transthyretin is a transport protein. It transports thyroid hormones in the plasma and cerebrospinal

Catenin Beta 1 - Pipeline Review, H2 2020SummaryCatenin Beta 1 (Beta Catenin or CTNNB1) pipeline Target constitutes close to 14 molecules. Out of which approximately 12 molecules are developed by companies and remaining by the universities/institutes. The latest report Catenin Beta 1 - Pipeline Review, H2 2020, outlays comprehensive information on the Catenin Beta 1 (Beta Catenin or CTNNB1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (M

Glycoprotein 41 (gp41) - Pipeline Review, H2 2020SummaryGlycoprotein 41 (gp41) - Gp41 or glycoprotein 41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells. It is a subunit of the envelope protein complex of retroviruses. The interaction of gp41 fusion peptides with the target cell causes a formation of an intermediate structure which bridges and fuses the viral and host membranes together. Glycoprotein 41 (gp41) pipeline Ta

20s Proteasome - Pipeline Review, H2 2020SummaryAccording to the recently published report '20s Proteasome - Pipeline Review, H2 2020'; 20s Proteasome pipeline Target constitutes close to 9 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes. 20s Proteasome - 20S proteasome is the catalytic core of the 26S proteasome, the central protease of the ubiquitin pathway of protein degradation. It is commonly associated with regulator

C5a Anaphylatoxin Chemotactic Receptor 1 - Pipeline Review, H2 2020SummaryC5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) pipeline Target constitutes close to 9 molecules. Out of which approximately 7 molecules are developed by companies and remaining by the universities/institutes. The latest report C5a Anaphylatoxin Chemotactic Receptor 1 - Pipeline Review, H2 2020, outlays comprehensive information on the C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) targeted therapeutics,

Glucagon Like Peptide 2 Receptor - Pipeline Review, H2 2020SummaryGlucagon Like Peptide 2 Receptor (GLP2R) - Glucagon-like peptide 2 receptor (GLP-2R) is a protein encoded by the GLP2R gene. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut. GLP2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. GLP2 prevents intestinal hypoplasia resulting from t

Metabotropic Glutamate Receptor 2 - Pipeline Review, H2 2020SummaryAccording to the recently published report 'Metabotropic Glutamate Receptor 2 - Pipeline Review, H2 2020'; Metabotropic Glutamate Receptor 2 (GPRC1B or MGLUR2 or GRM2) pipeline Target constitutes close to 12 molecules. Out of which approximately 11 molecules are developed by companies and remaining by the universities/institutes. Metabotropic Glutamate Receptor 2 (GPRC1B or MGLUR2 or GRM2) - Metabotropic glutamate receptor 2 is a

Metabotropic Glutamate Receptor 3 - Pipeline Review, H2 2020SummaryMetabotropic Glutamate Receptor 3 (GPRC1C or MGLUR3 or GRM3) pipeline Target constitutes close to 9 molecules. Out of which approximately 7 molecules are developed by companies and remaining by the universities/institutes. The latest report Metabotropic Glutamate Receptor 3 - Pipeline Review, H2 2020, outlays comprehensive information on the Metabotropic Glutamate Receptor 3 (GPRC1C or MGLUR3 or GRM3) targeted therapeutics, compl

Metabotropic Glutamate Receptor 5 - Pipeline Review, H2 2020SummaryMetabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Metabotropic glutamate receptor 5 (mGluR5) is a G protein-coupled receptor. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol calcium second messenger system and generates a calcium activated chloride cu

Hepatitis C Virus Envelope Protein E2 - Pipeline Review, H2 2020SummaryAccording to the recently published report 'Hepatitis C Virus Envelope Protein E2 - Pipeline Review, H2 2020'; Hepatitis C Virus Envelope Protein E2 pipeline Target constitutes close to 9 molecules. Out of which approximately 3 molecules are developed by companies and remaining by the universities/institutes. Hepatitis C Virus Envelope Protein E2 - E2 is a viral structural protein found in the hepatitis C virus. It is present

Fibroblast Growth Factor 2 - Pipeline Review, H2 2020SummaryFibroblast Growth Factor 2 (Basic Fibroblast Growth Factor or Heparin Binding Growth Factor 2 or FGF2) pipeline Target constitutes close to 10 molecules. Out of which approximately 7 molecules are developed by companies and remaining by the universities/institutes. The latest report Fibroblast Growth Factor 2 - Pipeline Review, H2 2020, outlays comprehensive information on the Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor o

Insulin Like Growth Factor I - Pipeline Review, H2 2020SummaryInsulin Like Growth Factor I (Mechano Growth Factor or Somatomedin C or IGF1) - Insulin-like growth factor 1 (IGF-1) also called somatomedin C is a protein encoded by the IGF1 gene. It stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin. It plays a role in synapse maturation. It acts as a ligand for IGF1R. It binds to the alpha subunit of IGF1R, leading to t

Insulin Like Growth Factor II - Pipeline Review, H2 2020SummaryAccording to the recently published report 'Insulin Like Growth Factor II - Pipeline Review, H2 2020'; Insulin Like Growth Factor II (Somatomedin A or T3M 11 Derived Growth Factor or IGF2) pipeline Target constitutes close to 7 molecules. Out of which approximately 2 molecules are developed by companies and remaining by the universities/institutes. Insulin Like Growth Factor II (Somatomedin A or T3M 11 Derived Growth Factor or IGF2)

Soluble Guanylate Cyclase - Pipeline Review, H2 2020SummarySoluble Guanylate Cyclase (sGC or EC 4.6.1.2) pipeline Target constitutes close to 29 molecules. Out of which approximately 26 molecules are developed by companies and remaining by the universities/institutes. The latest report Soluble Guanylate Cyclase - Pipeline Review, H2 2020, outlays comprehensive information on the Soluble Guanylate Cyclase (sGC or EC 4.6.1.2) targeted therapeutics, complete with analysis by indications, stage of d

Cyclin Dependent Kinase 2 - Pipeline Review, H2 2020SummaryCyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 2.7.11.22) - Cyclin-dependent kinase 2 is an enzyme encoded by the CDK2 gene. CDK2 is the catalytic subunit of the cyclin-dependent protein kinase complex which regulates progression through the cell cycle. Activity of CDK2 is especially critical during the G1 to S phase transition. CDK2 associates with and regulated by other subunits of the com