DailyUpdates was launched in 2002 by the pharmaceutical analysts LeadDiscovery and represents the first "newsfeed" that identifies breaking scientific publications with drug development potential. Using proprietary data retrieval strategies LeadDiscovery selects daily 1,000 PubMed articles and press releases.  The selected articles and releases are then scanned by an industrial research panel which judges those articles considered to be of greatest benefit for the drug development sector. Selected publications as well as press releases are then listed on DailyUpdates six therapeutic channels that match core R&D areas; Oncology Channel; CNS disorders; Cardiovascular disease; Metabolic and Hormonal disorders; Immunology, Inflammation & Infection; Internal Medicine.

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DailyUpdates by e-mail - the publication tracker for the drug discovery community

Oncology Channel - sample 30th March 2004


If this icon appears after any of our listed articles, the author is able to provide reprints. Articles denoted by Licensing Op. describe data relevant to licensing opportunities. The report icon, , links through to full analyses relating to pharmaceutical/market developments relating to this work

Today's top news stories

Cell Genesys Reports Synergistic Antitumor Activity for GVAX(R) Cancer Vaccine Plus Docetaxel Chemotherapy in Preclinical Studies
(Ed: For an analysis of cancer vaccine technology click here)

Spectrum Pharmaceuticals Announces Presentation of New Data on Satraplatin in Prostate Cancer at AACR

EntreMed's Immunomodulator Induces Long-Term Anti-Tumor Activity in Preclinical Models

Vion Initiates Phase II Trial of CLORETAZINE(TM) (VNP40101M) In Patients with Acute Myeloid Leukemia or Myelodysplastic Syndromes

SuperGen to Report Dacogen(TM) Phase III Study Results and Host Conference Call on Wednesday, March 31st

Kosan's AACR Data Indicates Strong Synergy of Hsp90 Inhibitor, 17-AAG, in Preclinical Combination Chemotherapy Studies

MedImmune and Cerus to Present Data on Novel Vaccine Technology's Potential to Help Treat and Prevent Cancers

Pharmacyclics Announces Data Demonstrating Novel Mechanism and Support For Ongoing Clinical Trials of Xcytrin in Hematologic and Other Cancers

Aegera Initiates Phase 1 Oncology Clinical Trial of XIAP Antisense Designed to Stimulate Apoptotic Cell Death in Cancer Cells
(Ed: For an analysis of IAP-related therapeutics click here)

CombinatoRx Presents Dual Action Anti-Cancer Drug at AACR Conference

Nereus Pharmaceuticals Reports Positive Preclinical Results of Anti-Cancer Drug Candidates Derived from Marine Microbes at AACR Annual Meeting

Peregrine's VTA & Docetaxel Combination Therapy Inhibits Human Breast Cancer Growth by 93% in Pre-Clinical Studies
(Ed: For an analysis of cytotoxics click here)

Exelixis Describes the Discovery of Novel Cancer Targets at AACR

Ligand Pharmaceuticals Inc.'s Targretin Synergizes With Chemotherapeutic Agents To Arrest NSCLC Growth and Prevents or Reverses Acquired Paclitaxel And Taxol Resistance In NSCLC And Advanced Breast Cancer

AVANIR Pharmaceuticals (AVN) Presents Additional Data On Novel Anti-Cancer Compounds At American Association For Cancer Research Meeting

New Study Expands On Effectiveness Of Ariad Pharmaceuticals' Oncology Product, AP23464, In Gleevec-Resistant Leukemia Cells

Researchers Report Coley Pharmaceutical Group's TLR9 Agonist Strongly Enhances Tumor Response To Radiotherapy In Animal Model

Array BioPharma Release: Investigational MEK Inhibitor, ARRY-142886 (AZD6244), Combats Cancer Growth

Spectrum Pharmaceuticals Announces Presentation Of New Data On Satraplatin In Prostate Cancer At American Association For Cancer Research

Ecopia BioSciences Inc. Presents Preclinical Data To The American Association For Cancer Research On Its Anticancer Agent

Altor BioScience Corporation Reports Advancements In Its Soluble T-cell Receptor-Based Technology Programs

NeoPharm Announces New Approach For Combination Therapy By Entrapping Two Drugs In Single Liposome Using NeoLipid Technology
(Ed: For an analysis of drug delivery technology click here)

GPC Biotech AG Presents Updates On Three Oncology Drug Development Programs At American Association For Cancer Research

Oxigene shares up as cancer drug effective in mice

New Study Expands on Effectiveness of ARIAD's Oncology Product, AP23464, in Gleevec-Resistant Leukemia Cells

All of today's news stories updated every 30 minutes

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PharmaReports

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Subscription to targeted DailyUpdates channels

  • Oncology
  • CNS disorders
  • Cardiovascular disease
  • Metabolic & Hormonal disorders
  • Immunology, Inflammation & Infection
  • Internal Medicine (GI, GU & Intestinal tracts)

Recent journal articles featuring Licensing/Collaborative opportunities

Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity. Int J Cancer. 2004 May 1;109(5):685-90.


Most recent journal article entries

Synthesis and biological activity of selective azasugar-based TACE inhibitors. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1569-72.
(Ed:In addition to this PharmaReport on rheumatoid arthritis therapeutics, one indication for TACE inhibitors, click here for a more general analysis of Cytokine-, Chemokine-, and Growth Factor-therapeutics)

Non-peptide alpha v beta 3 antagonists. Part 7: 3-Substituted tetrahydro-naphthyridine derivatives. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1049-52.
(Ed: This drug class is indicated for the prevention of tumor angiogenesis, the development of osteoporosis and the progression of rheumatoid arthritis. These PharmaReports offer insights into these fields)

Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Ther. 2004 Mar 12 [Epub ahead of print].

Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity. Biochem Pharmacol. 2004 Apr 1;67(7):1327-36.

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1411-6
(Ed:Click here for a general analysis of Cytokine-, Chemokine-, and Growth Factor-therapeutics)

Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR. Bioorg Med Chem Lett. 2004 Feb 23;14(4):909-12.

Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors. Int J Oncol. 2004 Apr;24(4):893-900.


Selected analyses of pharmaceutical/market development relating to today's selected publications (click on title or the icon next to publications listed above):


Previous entries

Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival (phase Ib/II). Clin Cancer Res. 2004 Mar 1;10(5):1580-7.

Complete response of severe symptomatic bone marrow metastases from heavily pretreated breast cancer with a 3-weekly trastuzumab schedule. A clinical case. Anticancer Res. 2004 Jan-Feb;24(1):317-9.

Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy. Clin Cancer Res. 2004 Mar 1;10(5):1843-52.

 

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