DailyUpdates by e-mail - the publication tracker for the drug discovery community

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Delivering breaking publications preselected for their drug discovery importance, DailyUpdates was set up by LeadDiscovery as a "first of its kind" service to stimulate the identification and development of new therapeutics. DailyUpdates has now been advanced to incorporate BioPortfolio's BioNews service together offering the first tracker of press releases and scientific publication. This mail is a one-off to inform you of this new service - if you find this free service of use and you wish to continue receiving alerts please register. Likewise please feel free to distribute this mail to colleagues who may find DailyUpdates of use.

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Most recent journal article entries

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders Nat Genet. 2003 Apr 14 [epub ahead of print]

The two faces of IKK and NF-{kappa}B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion Nat Med. 2003 Apr 7

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity Nat Med. 2003 May;9(5):582-8  

Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females Hum Mol Genet. 2003 May 15;12(10):1101-10.

Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles J Virol. 2003 May 15;77(10):6087-92.

Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients Cancer Gene Ther. 2003 May;10(5):341-52.

Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon Cancer Gene Ther. 2003 May;10(5):388-95.

Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects Cephalalgia. 2003 May;23(4):287-292

Overexpression of PACAP in Transgenic Mouse Pancreatic beta-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes Diabetes. 2003 May;52(5):1155-1162.

A Novel Role for CD36 in VLDL-Enhanced Platelet Activation Diabetes. 2003 May;52(5):1248-55.

Effects of Sildenafil (Viagra) on Human Myocardial Contractility, In Vitro Arrhythmias, and Tension of Internal Mammaria Arteries and Saphenous Veins J Cardiovasc Pharmacol. 2003 May;41(5):734-743.

Preischemic and Postischemic Administration of AEOL10113 Reduces Infarct Size in a Rat Model of Myocardial Ischemia and Reperfusion J Cardiovasc Pharmacol. 2003 May;41(5):714-9.

SNC-80-induced Preconditioning: Selective Activation of the Mitochondrial Adenosine Triphosphate-gated Potassium Channel J Cardiovasc Pharmacol. 2003 May;41(5):744-750.

The Novel Anti-inflammatory Compound, Lisofylline, Prevents Diabetes in Multiple Low-Dose Streptozotocin-Treated Mice Pancreas. 2003 May;26(4):E99-E104.

Treatment for Hyperglycemia Promotes Pancreatic Regeneration in Rats Without CCK-1 Receptor Gene Expression Pancreas. 2003 May;26(4):368-74.

Receptor for AGE (RAGE) Mediates Neointimal Formation in Response to Arterial Injury Circulation. 2003 Apr 28 [epub ahead of print]

Characterization of a family of endogenous neuropeptide ligands for the G protein- coupled receptors GPR7 and GPR8 Proc Natl Acad Sci U S A. 2003 Apr 25 [epub ahead of print]

Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss Arthritis Res Ther. 2003;5(1):R32-9  

The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis J Bone Miner Metab. 2003;21(3):161-5.

Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis J Pharmacol Sci. 2003;91(4):305-312.  

Effect of TTC-909 on Cerebral Infarction Following Permanent Occlusion of the Middle Cerebral Artery in Stroke Prone Spontaneously Hypertensive Rats J Pharmacol Sci. 2003;91(4):305-312.

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia Nat Genet. 2003 Apr 21 [epub ahead of print]

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Entremeds Investigational Cancer Drug Shows Promise; Shares Skyrocket For Second Day (Pharmaceutical Executive) - from DailyUpdates' oncology channel

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