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Tumor Necrosis Factor Superfamily - R&D Systems
This level of cross species conservation is much lower than that shown by other members of the TNFSF.
69 FasL: Fas ligand (FasL) is a highly conserved, 40 kDa transmembrane glycoprotein that occurs as either a membrane bound protein or a circulating homotrimer.
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Activin/Inhibin - R&D Systems
20 Mouse to human, each counterpart chain is approximately 95% conserved at the aa residue level.
As with other TGF-beta type II receptors, ActRII's extracellular region contains a cysteine-rich domain with 10 conserved cysteines.
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Multiple Sclerosis: Immune Cell Access to the Central Nervous System - R&D Systems
110 Integrins The integrins make up a well-conserved family of cell adhesion proteins.
However, most have a conserved catalytic domain, an inhibitory pro-peptide region, and a C-terminal hemopexin domain.
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Fibroblast Growth Factors (FGFs) - R&D Systems
To date, the FGF superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids.
65 Entry into the nucleus is associated with FGF-induced effects such as casein kinase II activation, which is necessary for cell-cycle progression and proliferation.
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Chemokines III - R&D Systems
Chemokines are divided into subfamilies based on conserved aa sequence motifs.
Most family members have at least four conserved cysteine residues that form two intramolecular disulfide bonds.
These proteins are highly conserved between species.
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NKG2D and its Ligands - R&D Systems
32 Structural conservation is also indicated by the fact that, although the MICA and MICB proteins of various primate species are highly diverse, they are readily recognized by receptors on human intestinal epithelial.d T cells.
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Interleukin-10 (IL-10) Family - R&D Systems
More than 80% of the 50 aa that generate IL-10's dimeric structure are conserved in IL-19, suggesting it likely forms noncovalent dimers.
47,48 The mature molecule contains three potential N-linked glycosylation sites plus four cysteines, only two of which are conserved in IL-10.
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Wnt Receptors and Pathways - R&D Systems
The Wnt ligands are a family of 19 molecules that are secreted, vary in length between 350 and 400 amino acids (aa), possess 22 to 24 conserved cysteines, and show 20%-85% aa identity within the family.
Although highly conserved, it may only be needed to maintain receptor conformation.
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Cytolytic Granule-mediated Apoptosis - R&D Systems
In the case of CD4 + T cells, recognition occurs via antigen-bound MHC II, while CD8 + CTLs recognize antigen displayed by MHC I.
131 Interestingly, L4-100 kDa appears to suppress only human Granzyme B and not rodent, despite the conserved nature of the Granzyme.
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Citations Search
(2006) Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.
(0003747) - - Products: Altered Sites ® II Mammalian in vitro Mutagenesis System | pALTER ® -MAX Vector 44.
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Citations Search
- Notes: The transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) occurs in cells as the transcriptional activator liver-enriched activating protein (LAP) and, in-truncated form, as liver-enriched inhibitory protein (LIP), which inhibits transcription.-Previous studies have shown that growth hormone (GH) promotes dephosphorylation of both LAP and LIP.-This study...
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Citations Search
Sequence analysis was then used to identify a conserved Ets transcription factor binding site within the putative il7r promoter region.
(0003451) - - Products: Dual-Luciferase ® Reporter 1000 Assay System | Dual-Luciferase ® Reporter Assay System | Dual-Luciferase ® Reporter Assay System 10-Pack | Gel Shift Assay Core System | Gel Shift Assay System |...
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Citations Search
(0003894) - - Products: Dual-Luciferase ® Reporter Assay System | ImProm-II™ Reverse Transcriptase | pGL3-Control Vector | pRL-TK Vector | T7 RiboMAX™ Express Large Scale RNA Production System 4.
Sequence analysis was then used to identify a conserved Ets transcription factor binding site within the putative il7r promoter region.
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Citations Search
(2006) Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.
(0003747) - - Products: Altered Sites ® II Mammalian in vitro Mutagenesis System | pALTER ® -MAX Vector 44.
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Citations Search
(2006) Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.
(0003499) - - Products: pGEM ® -T Vector System I | pGEM ® -T Vector System II | pSI Mammalian Expression Vector 4.
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Citations Search
- Notes: The transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) occurs in cells as the transcriptional activator liver-enriched activating protein (LAP) and, in-truncated form, as liver-enriched inhibitory protein (LIP), which inhibits transcription.-Previous studies have shown that growth hormone (GH) promotes dephosphorylation of both LAP and LIP.-This study...
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Citations Search
Sequence analysis was then used to identify a conserved Ets transcription factor binding site within the putative il7r promoter region.
(0003451) - - Products: Dual-Luciferase ® Reporter 1000 Assay System | Dual-Luciferase ® Reporter Assay System | Dual-Luciferase ® Reporter Assay System 10-Pack | Gel Shift Assay Core System | Gel Shift Assay System |...
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Citations Search
(0003894) - - Products: Dual-Luciferase ® Reporter Assay System | ImProm-II™ Reverse Transcriptase | pGL3-Control Vector | pRL-TK Vector | T7 RiboMAX™ Express Large Scale RNA Production System 4.
Sequence analysis was then used to identify a conserved Ets transcription factor binding site within the putative il7r promoter region.
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Citations Search
- Notes: The transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) occurs in cells as the transcriptional activator liver-enriched activating protein (LAP) and, in-truncated form, as liver-enriched inhibitory protein (LIP), which inhibits transcription.-Previous studies have shown that growth hormone (GH) promotes dephosphorylation of both LAP and LIP.-This study...
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Citations Search
(0003894) - - Products: Dual-Luciferase ® Reporter Assay System | ImProm-II™ Reverse Transcriptase | pGL3-Control Vector | pRL-TK Vector | T7 RiboMAX™ Express Large Scale RNA Production System 6.
Sequence analysis was then used to identify a conserved Ets transcription factor binding site within the putative il7r promoter region.
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Citations Search
- Notes: The transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) occurs in cells as the transcriptional activator liver-enriched activating protein (LAP) and, in-truncated form, as liver-enriched inhibitory protein (LIP), which inhibits transcription.-Previous studies have shown that growth hormone (GH) promotes dephosphorylation of both LAP and LIP.-This study...
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Citations Search
- Notes: The transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) occurs in cells as the transcriptional activator liver-enriched activating protein (LAP) and, in-truncated form, as liver-enriched inhibitory protein (LIP), which inhibits transcription.-Previous studies have shown that growth hormone (GH) promotes dephosphorylation of both LAP and LIP.-This study...
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Cell Imaging Protocols and Applications Guide
Antibody Species (subclass) Application and Recommended Dilution 1 Known Species Cross-Reactivity Catalog Number Anti-Human BNDF pAb Chicken (IgY) Western 1I¼g/ml; ELISA 1I¼g/ml; ICC 1a€“10I¼g/ml; IHC 10a€“15I¼g/ml; BN 10I¼g/ml Human, mouse, rat, rabbit 2 and quail 2 Cat.# G1641 Anti-Rat CNTF pAb Chicken (IgY) Western 1I¼g/ml; ELISA...
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Cell Signaling Protocols and Applications Guide
These evolutionarily conserved pathways are organized in three-kinase modules consisting of a MAP kinase, an activator of MAP kinase (MAP Kinase Kinase or MEK) and a MAP Kinase Kinase Kinase (MEK Kinase, MEKK, or MAPK Kinase Kinase).
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Expression Analysis Protocols and Applications Guide
Compared to many other commercially available systems that require 10a€“25I¼g of total RNA template, the ChipShota„¢ Labeling Systems allow users to conserve limited RNA template and increase the number of replicates performed.
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