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Citations Search
(2003) Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.
Results suggest that BDNF might be beneficial for the treatment of striatonigral degenerative disorders, including Huntington's disease.
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Citations Search
(2003) Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.
Results suggest that BDNF might be beneficial for the treatment of striatonigral degenerative disorders, including Huntington's disease.
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master_table - The Jackson Laboratory
and Jinnah, H.A., Abnormal motor behavior and vestibular dysfunction in the stargazer mouse mutant, Neuroscience, 127 (2004) 785-96.
and Sands, M.S., Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function, J Clin Invest, 101 (1998) 1394-400.
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mmrremutationsh23J - The Jackson Laboratory
The mutant mice exhibit a head bobbing and moderate circling behavior and a failure to swim.- Auditory brain stem response ( ABR ) analysis determined that phenotypic mutant mice are deaf.
Discussion Shaker 2 and shaker 2 2J were previously identified as mouse mutations in the Myo15 gene.- The human ortholog of unconventional myosin XV has been described as the gene that...
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Discovery Strategies 2002 - The Jackson Laboratory
High-throughput phenotype screens are underway in several focus areas including motor function, epilepsy, neural obesity, learning and memory, affective disorders, sensorimotor gating and vision.
Lower throughput screens for mice with mutations affecting ingestive behavior and smell are also underway and are being refined.
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Discovery Strategies 2005 - The Jackson Laboratory
injection.- Results from the elevated plus maze assay confirmed that buspirone reduced anxiety related behavior in mice, concomitant with a short term reduction in locomotor activity.- However, assays examining metabolism and immunology also showed dramatic effects in response to buspirone.- Glucose excursion was increased following an oral glucose tolerance test and insulin...
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Kenneth Johnson Staff Research Page - The Jackson Laboratory
Mouse Mutations Causing Hearing and Balance Defects Many of the mutations that cause deafness in mice also cause circling or head tossing behaviors; however, hearing impairment is sometimes associated with other deviant phenotypes as well.
The other two mutants exhibit moderate circling behavior but have normal hearing and appear to identify new genes underlying this...
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Richard Smith Staff Research Page - The Jackson Laboratory
Howell Research Administrative Assistant: Norma Buckley - - Research: Ophthalmic Pathology New ocular phenotypes are frequently identified with spontaneous mutations, in genetically engineered mice, and in Jackson Laboratory mutagenesis programs that include the Neuroscience Mutagenesis Facility, the Mouse Heart, Lung, Blood, and Sleep Disorders Center, and those of individual...
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Hampton Research
Proteins that initially resist crystallization can sometimes by coaxed to crystallize if a suitable ligand can be identified that improves the behavior of the protein in solution.
Crystals without disorder were observed with orthorhombic crystals P21212 only.
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Antibodies in the News (Archive)
To gain a clearer understanding of CII's role in the pathogenesis of RA, researchers at Queen Mary, University of London and others studied its behavior within an inflamed joint, when modified by oxidants linked to inflammation or by ribose, a five-carbon sugar common to all living cells.
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Accelrys - MS Modeling Quantum and Catalysis Tools - CASTEP Scientific References
Brito, Studies on the behavior of mixed-metal oxides: Structural, electronic, and chemical properties of beta-FeMoO4, J.
Robertson, Behavior of hydrogen in high dielectric constant oxide gate insulators, Appl.
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Risk for Diseases
- Those attributes (genetic, environmental or behavioral) of the individual that increase the probability of the disease outcome are called “risk factors.” - Five lines of human evidence may support the cause-effect relationship conferred by risk factors (Table 1).
- Such events are often predicated or influenced by genetic risk factors that are immutable to change...
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Bacterial Endocarditis
5-7 Mitral valve prolapse represents a spectrum of valvular changes and clinical behavior.
This is a progressive disorder that has a spectrum of manifestations.
Status Following Cardiovascular Procedures Many reparative cardiac procedures do not modify the patient's long-term risk for infective endocarditis, which continues indefinitely ( Table 1 ).
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Systemic Diseases
No other systemic diseases or conditions have been studied so extensively, although several other disorders may be linked to dental diseases.
They also demonstrate more behavioral abnormalities as preschoolers ( 133 ) and may have attention deficit hyperactivity disorder ( 10 ).
Behavioral problems in low-birth weight preschoolers.
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Antibody Patents
Recently significant progress has been made to generate recombinant smaller antibody fragments with improved tissue penetration and favorable pharmacological behavior, also humanized or de novo human antibodies have been produced which do not induce xenograft immune responses in patients.
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Accelrys - MS Modeling Quantum and Catalysis Tools - CASTEP Scientific References
Robertson, Behavior of hydrogen in high dielectric constant oxide gate insulators, Appl.
Rosseinsky, LiBC electronic, vibrational, structural, and low-temperature chemical behavior of a layered material isoelectronic with MgB2, Phys.
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Accelrys - Case Studies - Accelrys and IBM Accelerate Virtual Screening at Synt:em
Pep:trans Pep:trans is a unique way to modify the pharmacological behavior of compounds ranging from small molecules to more complex molecules like peptides and proteins by helping them to reach their targets across complex biological membranes.
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http://www.accelrys.com/accelrysworld/2004/presentations/aw2004_bratkovsky.pdf
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updated: 16/01/2006
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cy089901323p
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updated: 04/10/2005
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Prions - Abstract
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subject: Cell Sciences, Inc.
updated: 09/02/2005
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Prions - Abstract page 2
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subject: Cell Sciences, Inc.
updated: 09/02/2005
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Metals & Toxicants
Exposed animals have proven to be effective models of this condition, exhibiting similar sensitivity to the actions of Pb and replicating abnormal learning behaviors in exposed children.
Evidence from behavioral and neurophysiological investigations can be explained by increased NMDA receptor density on the bases of increased sensitivity to agonists and decreased...
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Chemicon Communications Newsletter 11-1
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author: Chemicon Marketing Dept.
updated: 18/06/2004
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http://www.chemicon.com/Resource/newsltrs/ns12-1_532.pdf
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Glial Cell Line-Derived Neurotrophic Factor (GDNF): A Comprehensive Review
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author: Promega Corporation
subject: Glial Cell Line-Derived Neurotrophic Factor (GDNF): A Comprehensive Review
updated: 22/04/2002
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