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Tumor Necrosis Factor Superfamily - R&D Systems
163, 164 TNF-alpha binding to TNFRII clearly has an effect on cells, however, inducing apoptosis in rhabdomyosarcoma (skeletal muscle tumor) cells, 165 and cell migration in Langerhans cells.
218 Osteoprotegerin/OPG: Named because of its ability to protect bone from breakdown (i.e., inhibit osteoclasts), OPG is a 55 kDa, 380 aa residue, naturally secreted member of the...
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Macrophage Stimulating Protein (MSP) - R&D Systems
15 Although MSP seems to impact some aspects of chemotaxis, it apparently does not provide a stimulus for monocyte migration out of the blood.
15, 28, 38 What MSP is suggested to do, however, is to induce the terminal differentiation of recently migrated and resident phagocytes into "mature" macrophages.
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Interleukin 16 (IL-16) - R&D Systems
23 IL-16-induced functions can be inhibited by a monomeric Fab of an anti-CD4 (OKT4) monoclonal antibody.
26 Specifically, the critical residue in native IL-16 responsible for inducing CD4 + cell migration by binding or activation of the IL-16 receptor appears to be Arg107.
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The Caspase-1 Inflammasome & its Role in Autoinflammatory Diseases - R&D Systems
During an inflammatory response, eosinophils and neutrophils migrate from the bloodstream into tissues.
37 The results of these studies indicate that inhibition of the interaction between pyrin and caspase-1 leads to an increase in caspase-1 activity and a subsequent increase in IL-1 beta secretion.
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Multiple Sclerosis: Immune Cell Access to the Central Nervous System - R&D Systems
In addition, proteases target components of the blood-brain barrier (BBB), providing pathways for leukocyte migration into the CNS parenchyma.
Transendothelial migration requires upregulation of several adhesion molecules.
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ELISpot Kits - R&D Systems
Sample Type: canine lymphocytes Catalog #: SEL781 Cutting edge: macrophage migration inhibitory factor is necessary for progression of experimental autoimmune encephalomyelitis.
Sample Type: mouse EL4 lymphoma cell line Catalog #: EL1865 Inhibition of matrix metalloproteinases protects mice from ascending infection and chronic disease manifestations resulting from...
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Chemokines III - R&D Systems
It also inhibits colony formation by myeloid progenitors.
Inhibitor studies reveal that migration in both directions requires the CXCR4 receptor, G-proteins, and phosphatidylinositol 3-kinase.
It also inhibits proliferation of hematopoietic progenitors and blocks development of the erythroid lineage.
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Cytokines in Wound Healing - R&D Systems
During inflammation, the formation of a blood clot re-establishes hemostasis and provides a provisional matrix for cell migration.
Immature keratinocytes produce matrix metalloproteases (MMPs) and plasmin to dissociate from the basement membrane and facilitate their migration across the open wound bed in response to chemoattractants.
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Interleukin-10 (IL-10) Family - R&D Systems
101,103 At the regional level, IL-10 may block immunostimulation by inhibiting Langerhans cell migration in response to proinflammatory cytokines.
113 This may have some importance in cell migration, particularly tumor cell metastases, where hyaluronectin is known to interrupt cell migration through extracellular space.
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Chemotaxis Bioassay - R&D Systems
Chemotaxis Assay Chemotaxis Assay using the standard 96-well Chemotaxis Chamber and using MTT or Alamar Blue to measure the number of cells migrating through the membrane.
Bubbles in either the lower or upper parts of the chamber will inhibit migration.
Failure to adequately remove all cells that have not migrated from the top of the filter will cause...
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ADAMs - R&D Systems
Sperm from fertilin β knockout mice is deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to egg zona pellucida.
elegans gene that has sequence similarity to ADAMTS1 yet lacks a TS domain, directs migration of distal tip cells by remodeling the basement membrane.
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Axon Guidance Cues at the Spinal Cord Midline - R&D Systems
Slits Slit proteins make up a family of multifunctional guidance cues with putative roles in regulating neuronal migration, 43 axonal and dendritic branching, 44-46 and axon guidance.
Exposure to soluble Axonin-1, or function blocking antibodies to Axonin-1 or NrCAM, inhibits commissural axon entry into floor plate explants.
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Apoptosis Detection Kits & Reagents - R&D Systems
Evidence of a "comet tail" shape and migration pattern indicates DNA Damage.
PARP Activity/Inhibition PARP Universal Colorimetric Assay This assay allows for the measurment of Polymerase (PARP) activity can be used to determine whether DNA is damaged, or to test for PARP inhibition.
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Citations Search
(1998) Restoration of beta1A integrins is required for lysophosphatidic acid-induced migration of beta1-null mouse fibroblastic cells J.
(1998) IL-1 produced and released endogenously within human islets inhibits beta cell function.
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Citations Search
(1998) Restoration of beta1A integrins is required for lysophosphatidic acid-induced migration of beta1-null mouse fibroblastic cells J.
(1998) IL-1 produced and released endogenously within human islets inhibits beta cell function.
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Citations Search
(1996) Sequence-independent inhibition of in vitro vascular smooth muscle cell proliferation, migration, and in vivo neointimal formation by phosphorothioate oligodeoxynucleotides J.
(1996) Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells.
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Citations Search
(1996) Sequence-independent inhibition of in vitro vascular smooth muscle cell proliferation, migration, and in vivo neointimal formation by phosphorothioate oligodeoxynucleotides J.
(1996) Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells.
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Citations Search
(1998) Neutralization of biological activity and inhibition of receptor binding by antibodies against human thrombopoietin Stem Cells 16 , 54-60.
Cell migration was assessed by using the CellTiter 96 A® AQueous Non-Radioactive Assay.
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Citations Search
- Notes: The authors used Promega's CellTiter 96 A® AQueous Non-Radioactive Cell Proliferation Assay to investigate the ability of phthalascidin, ecteinascidin 743 and a key intermediate to inhibit cell proliferation in a variety of human cancer cell lines.
(1998) Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in ...
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Citations Search
(1998) Inhibition of Human Hepatitis B Virus Replication by AT-61, a phenyl propenamide derivative, alone and in combination with (-)β-L-2', 3'-dideoxy-3'-thiacytidine Antimicrob.
(1996) Sequence-independent inhibition of in vitro vascular smooth muscle cell proliferation, migration, and in vivo neointimal formation by phosphorothioate...
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Citations Search
(1998) Neutralization of biological activity and inhibition of receptor binding by antibodies against human thrombopoietin Stem Cells 16 , 54-60.
Cell migration was assessed by using the CellTiter 96 A® AQueous Non-Radioactive Assay.
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Citations Search
(2000) Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells.
- Notes: The CellTiter 96 A® AQueous Non-Radioactive Cell Proliferation Assay (MTS/PMS) was used to determine the amount of Jurkat cells that had migrated through a chemotaxis chamber.
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Citations Search
Inhibition of Erg in human umbilical vein endothelial cells also resulted in a loss of viability and an increase in activation of caspase 3 and caspase 7.
(2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion and resistance to paclitaxel.
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Citations Search
- Notes: The authors used Promega's CellTiter 96 A® AQueous Non-Radioactive Cell Proliferation Assay to investigate the ability of phthalascidin, ecteinascidin 743 and a key intermediate to inhibit cell proliferation in a variety of human cancer cell lines.
(1998) Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in ...
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Citations Search
In addition, PC-3 cells transfected with several targets in the EphA2/ephrinA1 activation cascade including FRNK were subjected to an in vitro three-dimensional migration assay.
Overexpression of the protein caused 80-90% inhibition of cellular proliferation in two of the transitional cell carcinoma cell lines and inhibition of aneuploidy in the third.
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