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ATRA-IV liposomal retinoic acid
Home - Products & Technologies - Cancer Products ATRA-IV liposomal retinoic acid An investigational product What is ATRA-IV?
An oral formulation (Vesanoid ® , tretinoin, Hoffmann-La Roche ) is commercially available in the United States for treatment of acute promyelocytic leukemia.
ATRA-IV has received orphan drug designations from the US Food and Drug Administration...
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2006_AGEN_10K_full.pdf
smart science.
Forward- looking statements include statements about generating royalty revenue from QS- 21 in the 2010 timeframe, our timelines for performing and completing research, preclinical studies and clinical trials, timelines for releasing data from clinical trials, timelines for initiating new clinical trials, expectations regarding research, preclinical studies,...

author: ayildiz
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2006_AGEN_10K_full.pdf page 9


author: ayildiz
duplicates:
http://www.antigenics.com/investors/sec/10k/2006_AGEN_10-K.pdf
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printmgr file
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.
These forward- looking statements involve a number of risks and uncertainties that could cause actual results to differ materially from those suggested by the forward- looking statements.
ATRA is approved and marketed in an oral formulation call Vesanoid ® (tretinoin, Hoffman- LaRoche) for the treatment...

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31705-016.ps
ANTIGENICS INC.
Large accelerated filer ' Accelerated Filer I Non- accelerated filer ' Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b- 2 of the Exchange Act).
Furthermore, the statements speak only as of the date of this document, and we undertake no obligation to update or revise these statements.
ATRA is approved and marketed in an...

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31705-016.ps page 10


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Itching: Itching and Noninfectious Rashes: Merck Manual Home Edition
Section Skin Disorders Subject Itching and Noninfectious Rashes Itching Itching (pruritus) is a sensation that instinctively demands scratching.
Usually, pregnancy-related itching does not indicate any abnormality, but it can result from mild liver problems.
Prolonged scratching and rubbing can thicken and scar the skin.
Scaling most often affects the lower legs.
Harsh...
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Keratosis Pilaris: Itching and Noninfectious Rashes: Merck Manual Home Edition
Section Skin Disorders Subject Itching and Noninfectious Rashes Keratosis Pilaris Keratosis pilaris is a common disorder in which dead cells shed from the upper layer of skin plug the openings of hair follicles.
Keratosis Pilaris The cause is not known, although heredity probably plays a role.
Also, people with atopic dermatitis are more likely to have keratosis pilaris.
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Introduction: Sunlight and Skin Damage: Merck Manual Home Edition
Section Skin Disorders Subject Sunlight and Skin Damage Introduction The skin shields the rest of the body from the sun's rays.
UV light is classified into three types, ultraviolet A (UVA), ultraviolet B (UVB), and ultraviolet C (UVC), depending on its wavelength.
However, larger amounts of UV light damage DNA (the body's genetic material) and alter the amounts and kinds of...
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Chemotherapy: Prevention and Treatment of Cancer: Merck Manual Home Edition
Chemotherapy Drugs Class Examples How the Drug Works Side Effects Alkylating agents - Cyclophosphamide Chlorambucil Melphalan Form chemical bond with DNA, causing breaks in DNA and errors in replication of DNA Suppress bone marrow, injure lining of stomach, cause hair loss; may decrease fertility Antimetabolites - Methotrexate Cytarabine Fludarabine 6-Mercaptopurine 5-Fluorouracil...
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Acne: Merck Manual Home Edition
Drugs Used to Treat Acne Action Drug Selected Side Effects Comments Kills bacteria (applied topically) - Clindamycin Diarrhea (rarely) — - Erythromycin — Well tolerated - Benzoyl peroxide Dries the skin; may discolor clothing and hair Especially effective when combined with erythromycin Unclogs pores (applied topically) - Tretinoin Irritates skin; sensitizes skin to...
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Psoriasis: Itching and Noninfectious Rashes: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Rosacea: Itching and Noninfectious Rashes: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Itching: Itching and Noninfectious Rashes: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Index: TR: Merck Manual Home Edition
Train sickness see Motion sickness Tramsaminases Blood Tests Transcutaneous electrical nerve stimulation (TENS) Pain and Inflammation: Electrical Stimulation Treatment: Nondrug Pain Treatments Low Back Pain: Treatment in temporomandibular joint disorders Physical Therapy for Jaw Muscles Transdermal route (drug administration) Administration: Transdermal Route Transesophageal...
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Mental Retardation: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Refractive Disorders: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Vitamin A (retinol): Vitamins: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Introduction: Sunlight and Skin Damage: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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Hidradenitis Suppurativa: Bacterial Skin Infections: Merck Manual Home Edition
Search Recent Searches Index Sections A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders Cancer Children's Health Issues Digestive Disorders Disorders of Nutrition and Metabolism Drugs Ear, Nose, and Throat Disorders Eye Disorders Fundamentals Heart and Blood Vessel...
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THE MERCK MANUAL, Sec. 10, Ch. 117, Scaling Papular Diseases
This Publication Is Searchable The Merck Manual of Diagnosis and Therapy--- Section 10.
The cause is usually unknown.
Other causes include liver disease and graft-vs.-host disease.
Moderate to severe, often refractory, itching may be present.
Lesions may become large, scaly, and verrucous (hypertrophic lichen planus), particularly on the lower legs (see Plate 117-3-4 )....
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THE MERCK MANUAL, Sec. 10, Ch. 116, Disorders Of Hair Follicles And Sebaceous Glands
This Publication Is Searchable The Merck Manual of Diagnosis and Therapy--- Section 10.
Dermatologic Disorders--- Chapter 116.
Disorders Of Hair Follicles And Sebaceous Glands Topics Acne Rosacea Perioral Dermatitis Hypertrichosis Alopecia Pseudofolliculitis Barbae Keratinous Cyst Pseudofolliculitis Barbae Small pustules caused by irritation from hair that are more a foreign...
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THE MERCK MANUAL, Sec. 10, Ch. 115, Viral Skin Infections
This Publication Is Searchable The Merck Manual of Diagnosis and Therapy--- Section 10.
The course may be variable.
In addition, spontaneous disappearance of multiple warts in immunologically normal patients who later develop lifelong immunity needs further explanation.
Filiform warts are long, narrow, frondlike growths usually on the eyelids, face, neck, or lips.
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THE MERCK MANUAL, Sec. 10, Ch. 123, Pigmentation Disorders
This Publication Is Searchable The Merck Manual of Diagnosis and Therapy--- Section 10.
Pigmentation Disorders Topics Hypopigmentation Hyperpigmentation Hyperpigmentation Abnormally increased pigmentation.
Increased melanin deposition resulting in hyperpigmentation may be caused by hormonal changes (eg, in Addison's disease, pregnancy, or anovular pill use).
Melasma ...
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THE MERCK MANUAL, Sec. 10, Ch. 121, Disorders Of Cornification
This Publication Is Searchable The Merck Manual of Diagnosis and Therapy--- Section 10.
Dermatologic Disorders--- Chapter 121.
Disorders Of Cornification Topics Ichthyosis Keratosis Pilaris Calluses And Corns Keratosis Pilaris A common disorder of keratinization in which horny plugs fill the orifices of hair follicles.
Lesions are most prominent in cold weather and sometimes...
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