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The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel
Background and purpose: Pentamidine is a drug used in treatment of protozoal infections.

Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias associated with QTc prolongation and U-wave alterations.

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British Journal of Pharmacology:  Feb 24 2010 3:12PM
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