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Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
Wu Y et al.Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer.In this study CASP8 and maspin expression...
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Researchers Uncover Mechanism of Tobacco Carcinogen
A group of investigators has discovered that nicotine-derived nitrosamine ketone (NNK), a tobacco carcinogen, not only causes DNA and genetic alteration but also induces epigenetic alterations in the process of cancer formation, inhibiting tumor suppressor...
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TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer
Okada T et al.In this study, we examined the association of TWIST1 expression and TWIST1 methylation with clinicopathologic features in human primary colorectal tumors. The results of this study suggest that TWIST1 methylation may be a useful...
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Research and Markets: Pain Therapeutics - Drugs, Markets and Companies
Research and Markets (http://www.researchandmarkets.com/research/269a67/pain_therapeutics) has announced the addition of Jain PharmaBiotech's new report "Pain Therapeutics - Drugs, Markets and Companies" to their offering.This report describes the latest...
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Daiichi Sankyo files Japanese new drug application for Alzheimer's drug
Daiichi Sankyo Company has reported that its subsidiary, Asubio Pharma, has submitted a new drug application in Japan for the manufacturing and marketing of SUN Y7017, which was developed for the treatment of Alzheimer's type dementia, or AD.SUN Y7017 is an...
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Arkema increases Acrylic Acid and Acrylic Esters prices in Europe
- Arkema announces a 150/ton price increase for its acrylic monomers (acrylic acid, methyl acrylate, ethyl acrylate, butyl acrylate and 2-ethyl hexyl acrylate) in Europe, as of February 1st 2010 or as contracts allow.This price increase is necessary to...
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Establishing, maintaining and modifying DNA methylation patterns in plants and animals
_ Establishing, maintaining and modifying DNA methylation patterns in plants and animals.
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Cancer risk from 'third-hand smoke'
Nicotine residues on indoor surfaces can react with ambient gases to generate cancer-causing compounds, researchers in the US have found.The research is hoped to shed new light on the possible danger of 'third-hand smoke' - where toxins from tobacco fumes...
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Lysine methylation regulates the pRb tumour suppressor protein
Oncogene advance online publication, February 8, 2010.doi:10.1038/onc.2009. Lysine methylation regulates the pRb tumour suppressor protein.
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Precision molecular assembly
A finely tuned rare-earth metal catalyzes the exact interactions needed for site-selective molecular synthesis Figure 1: The interaction between a scandium-based catalyst (Sc+Cp*) and a silyl ether group (SiO) allows the highly selective addition of...
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New findings from SomaGenics, Inc. in the area of antisense technology published
Research findings, 'Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs,' are discussed in a new report.'Small hairpin RNAs (shRNAs) with 19-base-pair, or shorter, stems (short shRNAs [sshRNAs])...
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Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology
1Institute for Pathology, University Hospital Basel, Switzerland 2Division of Tumor Biology, The Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, USA 3Department of Pathology, Institute for Surgical Pathology,...
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Antisense Technology: New findings from SomaGenics, Inc. in the area of antisense technology published
Today's Medical & Research News Antisense Technology New findings from SomaGenics, Inc.in the area of antisense technology published February 6th, 2010 Printer-Friendly Version City:Santa Cruz State:California Country:United States Antisense Technology...
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DNA Methylation Could Change Gene Expression
at the Genome Institute of Singapore and The Scripps Research Institute have shown dramatic changes in DNA methylation as stem cells differentiate and the patterns revealed could influence transcription and gene expression.The results were published on...
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Scientists Map Epigenome of Human Stem Cells During Development
a Points Provide Big Picture of 'Human Epigenome During Critical Developmental Window04 Feb 2010 - Scientists at The Genome Institute of Singapore (GIS) and The Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail...
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Folate may protect women from pancreatic cancer
Increased intake of folate may reduce a womans risk of pancreatic cancer by 50 per cent, but folate levels are not associated with pancreatic cancer risk in men, says a new study supported by the National Institutes of Health.A study with 51,988 men and 57...
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Study findings on pharmaceuticals are outlined in reports from Sankyo Co., Ltd
According to recent research from Hiromachi, Japan, 'In the present study, we evaluated the effect of the novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-di-methyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl]-1H-pyrrolo[2,3-d]pyridazine (CS-526) on the...
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Special Focus On Epigenetics In GEN Feb. 1 Issue
Increasing numbers of research studies clearly demonstrate that genetics alone cannot explain the diversity of living organisms, reports Genetic Engineering & Biotechnology News (GEN).Also driving the development of such complexity is epigenetics, and...
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Folate may protect women from pancreatic cancer
Increased intake of folate may reduce a womans risk of pancreatic cancer by 50 per cent, but folate levels are not associated with pancreatic cancer risk in men, says a new study supported by the National Institutes of Health.A study with 51,988 men and 57...
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Pharmaceuticals: Study findings on pharmaceuticals are outlined in reports from Sankyo Co., Ltd.
Today's Medical & Research News Pharmaceuticals Study findings on pharmaceuticals are outlined in reports from Sankyo Co., Ltd.February 5th, 2010 Printer-Friendly Version City:Hiromachi Country:Japan Acid Reflux Drugs Gastroenterology Gastroesophageal...
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Research on hepatitis B virus cell biology published by scientists at Second Military Medical University, Inte
Scientists discuss in 'Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma' new findings in...
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International Team Maps Methylation Changes During Cellular Differentiation
Researchers from the Genome Institute of Singapore, the Scripps Research Institute, and elsewhere mapped and compared DNA methylation patterns in three human cell lines at progressive stages of development.Full-text access for registered users only.
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N-Methyl-D-Aspartate Glutamate Receptor Blockade Attenuates Lung Injury Associated With Experimental Sepsis
Aline A.da Cunha , PharmD, Vnia Pauli , BSc, Vasyl C. Saciura , BSc, Melissa G. Pires , PhD, Leandra C. Constantino , BSc, Bruna de Souza , PharmD, Fabricia Petronilho , MSc, Jarbas Rodrigues de Oliveira , PharmD, PhD, Cristiane Ritter , MD, PhD, Pedro...
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Boffins map epigenome of human stem cells during development
WASHINGTON: Scientists at The Scripps Research Institute and The Genome Institute of Singapore (GIS) have shown, through a map, how the human genome is modified during embryonic development."The cells in our bodies have the same DNA sequence," said Scripps...
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Scientists Map Epigenome Of Human Stem Cells During Development
Scientists at The Genome Institute of Singapore (GIS) and The Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development.This detailed mapping is a...
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