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Overexpression of translocator protein in inflammatory bowel disease: Potential diagnostic and treatment value
Inflammatory bowel diseases (IBDs), such as ulcerative colitis and Crohn's disease, are chronic inflammatory disorders that increase the risk for colorectal cancer.The mitochondrial translocator protein (TSPO) is a high-affinity drug- and cholesterol-binding...
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CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice
Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues.CCL2 is a chemokine that induces migration of monocytes, memory T cells, and...
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Stanozolol treatment for successful prevention of attacks of severe primary cryofibrinogenemia
Severe essential cryofibrinogenemia is rare in childhood, and both the diagnosis and the management are challenging for pediatricians.An 11-year-old male, who had already lost two digits following cold exposure, was referred after multiple visits to various...
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Stanozolol treatment for successful prevention of attacks of severe primary cryofibrinogenemia
Unal S et al.Severe essential cryofibrinogenemia is rare in childhood, and both the diagnosis and the management are challenging for pediatricians. An 11yearold male, who had already lost two digits following cold exposure, was referred after multiple...
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Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury
Laboratory Investigation advance online publication, February 8, 2010.doi:10.1038/labinvest.2010. Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute...
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Reports summarize colitis animal studies study results from University of Munster
Scientists discuss in 'Insulin-like growth factor 1-coated sutures improve anastomotic healing in an experimental model of colitis' new findings in colitis.'Exogenously applied insulin-like growth factor (rhIGF-1) may improve normal intestinal healing.
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Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate
Background and purpose: To validate a fluorescence approach for monitoring norepinephrine transporter (NET) transport rate in mature sympathetic terminals, and to determine how prejunctional muscarinic receptors affect NET rate.Experimental approach: Confocal...
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Iron Safety Hits AMAG Pharmaceuticals
Shares of AMAG Pharmaceuticals, Inc.(AMAG) traded as low as $37.70 today, down nearly 17% from the prior close of $45.25 due to purported safety concerns regarding Feraheme [ferumoxytol], the companys marketed product for the treatment of iron...
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Factor VIII polymer conjugates
The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.Description of the Invention SUMMARY OF THE INVENTION The...
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