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WITHDRAWN: Very strong synergy between modified RANTES and gp41 binding peptides leads to potent anti-HIV-1 activity [Article]
This article, published ahead of print on 28 July 2008, has been withdrawn by the authors.WITHDRAWN: Very strong synergy between modified RANTES and gp41 binding peptides leads to potent anti-HIV-1 activity [Article].
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Pharmacokinetic-Pharmacodynamic Assessment of Faropenem in a Lethal Murine-Bacillus anthracis Inhalation Post-Exposure Prophylaxis Model [Article]
Pharmacokinetic-Pharmacodynamic Assessment of Faropenem in a Lethal Murine-Bacillus anthracis Inhalation Post-Exposure Prophylaxis Model Stanley C.Gill*, Christopher M. Rubino, Jennifer Bassett, Lynda Miller, Paul G. Ambrose, Sujata M. Bhavnani, Amber...
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Changes in the Proteome of Candida albicans in Response to Azole, Polyene, and Echinocandin Antifungal Agents [Article]
The yeast Candida albicans is an opportunistic human fungal pathogen and cause of superficial and systemic infections in immunocompromised patients.The classes of antifungal agents most commonly used to treat Candida infections are the azoles, polyenes, and...
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Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species. [Article]
We studied three clinical isolates of Candida spp.(1 C. tropicalis and 2 C. glabrata ) isolated from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment while the others after the same treatment. These strains...
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ANTISTAPHYLOCOCCAL ACTIVITY OF ACHN-490 TESTED ALONE AND IN COMBINATION WITH OTHER AGENTS BY TIME-KILL ASSAY [Article]
Synergy time-kill studies of 47 MRSA strains with differing resistance phenotypes showed that combinations of sub-inhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against...
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Fluoroquinolone resistance in Streptococcus dysgalactiae subsp. equisimilis and evidence for a shared global gene pool with Streptoccocus pyogenes [Article]
Fluoroquinolone resistance in Streptococcus dysgalactiae subsp.equisimilis and evidence for a shared global gene pool with Streptoccocus pyogenes M. Pinho, J. Melo-Cristino, M. Ramirez*, and the Portuguese Group for the Study of Streptococcal...
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Correlation between in vitro activity of posaconazole and in vivo efficacy against Rhizopus oryzae infection in mice [Article]
We have evaluated the in vitro activity of posaconazole (PSC) against 50 clinical strains of Rhizopus oryzae using a broth microdilution method, the Neo-Sensitabs tablet diffusion method, and the minimal fungicidal concentration (MFC) determination.In...
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A Cutaneous Model of Invasive Aspergillosis [Article]
Cutaneous models have proven useful in studies of the pathogenesis and treatment of Gram-positive bacterial infections.Because cutaneous invasive aspergillosis (IA) occurs in the clinical setting, we sought to develop a non-lethal murine cutaneous model of...
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Crystal Structure of the Narrow-Spectrum OXA-46 Class D {beta}-lactamase: Relationship between Active Site Lysine Carbamylation and Inhibition by Polycarboxylates [Article]
Crystal Structure of the Narrow-Spectrum OXA-46 Class D -lactamase: Relationship between Active Site Lysine Carbamylation and Inhibition by Polycarboxylates Jean-Denis Docquier, Manuela Benvenuti, Vito Calderone, Francesco Giuliani, Dimos Kapetis, Filomena De...
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Occurence of ST-23 complex/phylogroup A Escherichia coli isolates producing extended-spectrum-AmpC (ESAC) {beta}-lactamase, in a French hospital. [Article]
Extended-spectrum AmpC -lactamase (ESAC) E.coli producers were investigated over a 5-year period. Occurence of ST-23 complex/phylogroup A Escherichia coli isolates producing extended-spectrum-AmpC (ESAC) {beta}-lactamase, in a French hospital. [Article]....
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